(4- (m- Chlorophenylcarbamoyloxy)- 2- butynyl)trimethylammonium Chloride

A drug that selectively activates certain subclasses of muscarinic receptors and also activates postganglionic nicotinic receptors. It is commonly used experimentally to distinguish muscarinic receptor subtypes.

Also Known As:

Networked: 43 relevant articles (1 outcomes, 3 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Honda, Kenji: 3 articles (02/2020 - 11/2004)
2.	Koga, Kohei: 3 articles (02/2020 - 11/2004)
3.	Eto, Fumihiro: 2 articles (02/2020 - 01/2019)
4.	Matsumoto, Taichi: 2 articles (02/2020 - 01/2019)
5.	Migita, Keisuke: 2 articles (02/2020 - 01/2019)
6.	Terada, Kazuki: 2 articles (02/2020 - 01/2019)
7.	Pavlov, Valentin A: 2 articles (01/2014 - 03/2006)
8.	Tracey, Kevin J: 2 articles (01/2014 - 03/2006)
9.	Barbosa, André Luiz Dos Reis: 1 article (05/2021)
10.	Batista, Jalles Arruda: 1 article (05/2021)

Related Diseases

1.	Xerostomia 01/01/1994 - "5. Our results suggest that the sialogogic effects of SNI-2011 and McN-A-343 are mediated by direct stimulation of M3 receptors in salivary glands and that SNI-2011 may prove useful in the management of xerostomia in patients with Sjögren's syndrome."
2.	Ganglion Cysts (Ganglion) 04/01/1988 - "Neither agonist evoked a maximum response at doses up to 10 mM. 4. The muscarinic ganglion stimulant, McN-A-343 yielded inconsistent results, depressing the field potential in some slices, but having no effect in others. " 06/01/1980 - "The muscarinic ganglion stimulating agent, McN-A-343 has unusual blocking actions on endplate currents (EPCs) at frog neuromuscular junctions. " 09/01/1971 - "Antagonism of the ganglion stimulating and parasympathetic actions of McN-A-343 by pilocarpine." 04/01/1969 - "A study of ganglionic denervation supersensitivity using McN-A-343 and histamine as ganglion stimulating agents." 05/01/1987 - "3. Doses of guanethidine (1 mg/kg) and pentacynium (1 mg/kg) blocking pressor responses to intravenous administration of the ganglion stimulants McN-A-343 and DMPP, respectively, did not affect responses to AA. "
3.	Astrocytoma (Pilocytic Astrocytoma) 05/01/1985 - "Studies with pirenzepine and McN-A343 in chick heart and astrocytoma cells." 05/01/1985 - "Muscarinic receptor-mediated phosphoinositide hydrolysis in 1321N1 astrocytoma cells is also insensitive to McN-A343 or AHR 602 and is antagonized only by relatively high concentrations of pirenzepine. "
4.	Specific Phobia 05/01/2000 - "On trial 2 in the elevated plus-maze, a model of specific phobia, the endogenous cholinergic system, nicotine, and the M(1) receptor agonist, McN-A-343, all mediate an anxiolytic effect, whereas stimulation of 5-HT(1A) receptors mediates an anxiogenic effect. "
5.	Bradycardia 05/05/1986 - "In pithed rats AF-DX 116 inhibits vagally-induced bradycardia, an M2 response, (ED50 32 micrograms/kg i.v.) in preference to the M1-mediated pressor response to McN-A-343 (ED50 211 micrograms/kg i.v.). " 04/01/1993 - "McN-A-343 ([4-hydroxy-2-butynyl]-1-trimethyl ammonium m-chlorocarbanilate chloride) (1 mg/kg i.v.) did not produce bradycardia. " 11/01/1971 - "McN-A-343 blocked sinus bradycardia caused by electrical stimulation of the right vagus, while bradycardia induced by administration of acetylcholine or nicotine into the sinus node artery was not modified." 04/01/1993 - "The low sensitivity of the neostigmine-induced bradycardia to pirenzepine, and the failure of McN-A-343 to evoke bradycardia, suggest the receptor on cardiac ganglion cells is not an M1-type.(ABSTRACT TRUNCATED AT 250 WORDS)" 09/01/1986 - "Mirroring the binding data, pirenzepine, dicyclomine and trihexyphenidyl showed a tenfold greater ability at inhibiting M1-receptor mediated ganglionic responses (McN A-343 pressor effect in pithed rats and nictitating membrane contraction in cats) than at inhibiting peripheral muscarinic responses in the heart and cardiovascular smooth muscle (vagal bradycardia in rats and cats and vagally-induced vasodilatation in cats). "

Related Drugs and Biologics

1.	cevimeline (Evoxac)
2.	Cholinergic Agents (Cholinergics)
3.	Pirenzepine
4.	Nicotine
5.	Anti-Anxiety Agents (Anxiolytics)
6.	Histamine (Histamine Dihydrochloride)
7.	Dimethylphenylpiperazinium Iodide
8.	Muscarinic M1 Receptor
9.	Muscarinic Receptors (Muscarinic Acetylcholine Receptor)
10.	Muscarine

Related Therapies and Procedures

1.	Denervation
2.	Intravenous Administration
3.	Intraventricular Infusions
4.	Ligation
5.	Intravenous Injections