A serotonin agonist-antagonist reversible effect on Na+-K+-ATPase activity in the developing rat brain.

Abstract

In brain of adult and developing rats the Na+-K+-adenosine triphosphatase (Na+-K+-ATPase) system seems to react to serotonin (5-HT) changes induced pharmacologically. A 5-HT agonist (quipazine) elicits a response of the enzyme activity in the cerebral cortex in vivo, which is neutralized with a 5-HT antagonist (methysergide). This effect was observed from day 21 to adulthood. Also in a state of 5-HT receptor hypersensitivity (rats treated early with 5,6-dihydroxytryptamine), the response of Na+-K+-ATPase to the 5-HT agonist was higher than without neurotoxic lesion of 5-HT paths. These data suggest an involvement of the Na+-K+-ATPase system in 5-HT receptor sensitivity in the rat brain.

• Authors: R J Hernández
• Journal: Developmental neuroscience (Dev Neurosci) Vol. 5 Issue 4 Pg. 326-31 ( 1982) ISSN: 0378-5866 [Print] Switzerland
• PMID: 6291893 (Publication Type: Journal Article)

Chemical References

• Quinolines
• Receptors, Serotonin
• Quipazine
• Sodium-Potassium-Exchanging ATPase
• 5,6-Dihydroxytryptamine
• Methysergide

Topics

• 5,6-Dihydroxytryptamine (pharmacology)
• Aging
• Animals
• Cerebral Cortex (drug effects, enzymology)
• Dose-Response Relationship, Drug
• Male
• Methysergide (pharmacology)
• Quinolines (pharmacology)
• Quipazine (analogs & derivatives, pharmacology)
• Rats
• Rats, Inbred Strains
• Receptors, Serotonin (drug effects)
• Sodium-Potassium-Exchanging ATPase (metabolism)