gamma-Acetylenic GABA in tardive dyskinesia.

Abstract

Brain gamma-aminobutyric acid (GABA) has been proposed to play a role in the modulation of extrapyramidal motor function. The effects of increasing brain GABA with gamma-acetylenic GABA (GAG), a drug that inhibits GABA transaminase, were evaluated in ten patients with stable tardive dyskinesia during a blind placebo-controlled trial. Drug effects during active treatment and two placebo periods were evaluated by scoring randomly sequenced videotapes of tardive dyskinesia and parkinsonian symptoms recorded weekly during a standardized examination. Tardive dyskinesia was significantly reduced, and preexisting parkinsonism increased slightly. The largest decrease in tardive dyskinesia symptoms occurred in patients receiving higher neuroleptic doses, suggesting an interaction between GABA and dopamine. Prolactin values increased but growth hormone values were unchanged. Psychiatric symptoms were also unchanged during GAG treatment.

• Authors: D E Casey, J Gerlach, G Magelund, T R Christensen
• Journal: Archives of general psychiatry (Arch Gen Psychiatry) Vol. 37 Issue 12 Pg. 1376-9 (Dec 1980) ISSN: 0003-990X [Print] United States
• PMID: 6108751 (Publication Type: Clinical Trial, Controlled Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Alkynes
• Aminocaproates
• Antipsychotic Agents
• gamma-Aminobutyric Acid
• 4-amino-5-hexynoic acid
• Prolactin
• Transaminases
• 4-Aminobutyrate Transaminase
• Dopamine

Topics

• 4-Aminobutyrate Transaminase (antagonists & inhibitors)
• Adult
• Aged
• Alkynes
• Aminocaproates (therapeutic use)
• Antipsychotic Agents (adverse effects)
• Brain (enzymology)
• Dopamine (metabolism)
• Dyskinesia, Drug-Induced (drug therapy, enzymology)
• Female
• Humans
• Male
• Middle Aged
• Parkinson Disease, Secondary (chemically induced, drug therapy, enzymology)
• Prolactin (blood)
• Transaminases (antagonists & inhibitors)
• gamma-Aminobutyric Acid (metabolism)