Facilitation of development of resistance to morphine analgesia by desglycinamide9-lysine vasopressin.

Desglycinamide(9)-lysine vasopressin facilitates development of resistance to the analgesic action of morphine in mice if morphine is administered before the peptide. Desglycinamide(9)-lysine vasopressin is not a morphine antagonist, and does not appear to cause either hyperalgesia or alteration of the response to the technique used for evaluating analgesia.
AuthorsW A Krivoy, E Zimmermann, S Lande
JournalProceedings of the National Academy of Sciences of the United States of America (Proc Natl Acad Sci U S A) Vol. 71 Issue 5 Pg. 1852-6 (May 1974) ISSN: 0027-8424 [Print] United States
PMID4525467 (Publication Type: Journal Article)
Chemical References
  • Amides
  • Analgesics
  • Peptides
  • Vasopressins
  • Morphine
  • Lysine
  • Glycine
  • Amides
  • Analgesics
  • Animals
  • Drug Resistance
  • Female
  • Glycine
  • Lysine
  • Mice
  • Mice, Inbred Strains
  • Morphine
  • Peptides (pharmacology)
  • Reaction Time (drug effects)
  • Vasopressins (pharmacology)

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