[Effect of lithium hydroxybutyrate on several heart function indices].

Abstract

DL50 of intraperitoneal lithium oxybutyrate administered to cats was found to amount to 724 mg/kg, while in doses of 13.5--360 mg/kg it increases the coronary blood flow volume in cats by 20.3--122.2 per cent, directly proportional to the dose. Lithium oxybutyrate prevents the chlorocalcium arrhythmia in rats and eliminates strophanthine-induced anemia in cats, surpassing an analogous effect of lithium chloride, potassium chloride, quinidine, novocainamide and isoptin. It raises the activity of the succinate dehydrogenase in the myocardium and weakens the ability of calcium chloride to reduce the glycogen content in the conduction system of the heart in rats.

• Authors: A A Stoliarchuk, N N Samoĭlov, A V Rychko, V S Umanets
• Journal: Farmakologiia i toksikologiia (Farmakol Toksikol) 1979 Jan-Feb Vol. 42 Issue 1 Pg. 37-41 ISSN: 0014-8318 [Print] Russia (Federation)
• Vernacular Title: Vliianie litiia oksibutirata na nekotorye pokazateli funktsii serdtsa.
• PMID: 421889 (Publication Type: English Abstract, Journal Article)

Chemical References

• Hydroxybutyrates
• RNA
• Glycogen
• Lithium
• Sodium
• Potassium

Topics

• Animals
• Arrhythmias, Cardiac (chemically induced, prevention & control)
• Cats
• Coronary Circulation (drug effects)
• Glycogen (metabolism)
• Hydroxybutyrates (pharmacology, therapeutic use)
• Lithium (pharmacology, therapeutic use)
• Myocardium (metabolism)
• Oxygen Consumption (drug effects)
• Potassium (metabolism)
• RNA (metabolism)
• Rats
• Sodium (metabolism)