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Procainamide (Procan)

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A derivative of PROCAINE with less CNS action. It also acts as a non-nucleoside inhibitor of DNA METHYLATION and has led to SYSTEMIC LUPUS ERYTHEMATOSUS.

Also Known As:

Procan; Pronestyl; Rhythmin; Apo-Procainamide; Apotex Brand of Procainamide Hydrochloride; Apothecon Brand of Procainamide Hydrochloride; Biocoryl; Bristol-Myers Squibb Brand of Procainamide Hydrochloride; Monarch Brand of Procainamide Hydrochloride; Novocainamide; Novocamid; Parke Davis Brand of Procainamide Hydrochloride; Pfizer Brand of Procainamide Hydrochloride; Procainamide Hydrochloride; Procamide; Procan SR; Procanbid; Sidmark Brand of Procainamide Hydrochloride; Uriach Brand of Procainamide Hydrochloride; Amide, Procaine; Hydrochloride, Procainamide; Procaine Amide; Benzamide, 4-amino-N-(2-(diethylamino)ethyl)-

Networked: 1008 relevant articles (72 outcomes, 96 trials/studies)

Relationship Network

Drug Context: Research Results

Organic Chemicals: 58
- Amides: 231
  - Benzamides: 80
    - Procainamide: 1008
- Carboxylic Acids: 83
  - Carbocyclic Acids
    - Benzoic Acids: 18
      - Benzamides: 80
        Procainamide: 1008
        N-propionylprocainamide: 56
        sematilide: 15
        desethylprocainamide: 6
        declopramide: 5
        4-hydroxy-N-(2-diethylaminoethyl)benzamide: 1
        procaine amide ethobromide: 1
        4-amino-N-(2-(diethylamino)ethyl)-3,5-dimethylbenzamide
        4-hydroxy-N-(3-diethylaminopropyl)benzamide
        4-nitroprocainamide
        4-nitrosoprocainamide
        N-acetyldeclopramide
        N-chloroprocainamide
        procainamide 4-hydroxylamine
        procainamide acryloyl polymer
        procainamide methacrylamide
      - Aminobenzoic Acids
        4-Aminobenzoic Acid: 376
        Procainamide: 1008
        N-propionylprocainamide: 56
        sematilide: 15
        desethylprocainamide: 6
        declopramide: 5
        4-hydroxy-N-(2-diethylaminoethyl)benzamide: 1
        procaine amide ethobromide: 1
        4-amino-N-(2-(diethylamino)ethyl)-3,5-dimethylbenzamide
        4-hydroxy-N-(3-diethylaminopropyl)benzamide
        4-nitroprocainamide
        4-nitrosoprocainamide
        N-acetyldeclopramide
        N-chloroprocainamide
        procainamide 4-hydroxylamine
        procainamide acryloyl polymer
        procainamide methacrylamide

Experts

1.	Trappe, Hans-Joachim: 3 articles (04/2010 - 05/2003)
2.	Berul, Charles I: 2 articles (09/2014 - 09/2003)
3.	Klein, George J: 2 articles (06/2014 - 10/2005)
4.	Krahn, Andrew D: 2 articles (06/2014 - 10/2005)
5.	Yee, Raymond: 2 articles (06/2014 - 10/2005)
6.	Gula, Lorne J: 2 articles (06/2014 - 10/2005)
7.	Skanes, Allan C: 2 articles (06/2014 - 10/2005)
8.	Hernández-Pando, Rogelio: 2 articles (03/2012 - 02/2004)
9.	Baeza, Isabel: 2 articles (03/2012 - 02/2004)
10.	Ibáñez, Miguel: 2 articles (03/2012 - 02/2004)

Related Diseases

1.	Ventricular Tachycardia 12/01/1986 - "However, the results of this study indicate that procainamide may be effective in suppressing the induction of sustained ventricular tachycardia at a relatively low plasma concentration, but not at a higher plasma concentration. " 03/01/1986 - "The efficacy of retrograde coronary venous delivery of procainamide for the management of spontaneous and inducible sustained ventricular tachycardia was evaluated and compared with systemic intravenous procainamide administration in 22 conscious dogs with permanent left anterior descending coronary artery occlusion. " 10/01/1991 - "Intravenous procainamide was used in six patients: one improved, and five had recurrence of polymorphous ventricular tachycardia. " 10/01/1989 - "Efficacy of procainamide on ventricular tachycardia: relation to prolongation of refractoriness and slowing of conduction." 05/08/1954 - "Resistant ventricular tachycardia cured with large doses of procainamide."
2.	Cardiac Arrhythmias (Arrythmia) 01/01/1986 - "When procainamide was withheld, VT resolved completely and no arrhythmia could be induced by programmed ventricular stimulation. " 12/01/1986 - "In these studies, we showed that NAPA has an elimination-phase half-life that is more than twice as long as procainamide and suggested that patient compliance and arrhythmia suppression might be improved if NAPA were used to circumvent the inconvenience of the frequent dosing schedule that has been recommended for procainamide. " 07/01/1988 - "Comparative bioequivalence and efficacy of two sustained-release procainamide formulations in patients with cardiac arrhythmias." 11/01/1952 - "The intramuscular administration of procaine amide; a safe and effective method for the treatment of cardiac arrhythmias." 04/01/1993 - "This report represents follow-up observations of a unique long-term study of patients on procainamide (PA) for various cardiac arrhythmias. "
3.	Atrial Fibrillation 03/01/1998 - "The results of the study suggest that intravenous procainamide is an effective and safe means for the rapid termination of atrial fibrillation of recent onset and that its success rate is inversely related to the size of the left atrium. " 01/01/1992 - "Intravenous procainamide conversion of postoperative atrial fibrillation is concluded to be effective and safe and can be recommended as the treatment of first choice in awake and nonintubated postoperative cardiac patients." 12/01/2007 - "This study of acute atrial fibrillation or flutter patients treated in the ED with IV procainamide suggests that this treatment is safe and effective in this setting. " 11/01/1980 - "The efficacy of intravenous procainamide, infused at 30 mg/min to a maximum dose of 20 mg/kg, in converting atrial fibrillation was evaluated under electrocardiographic and blood pressure control in 21 patients. " 11/01/1980 - "Efficacy of intravenous procainamide infusion in converting atrial fibrillation to sinus rhythm. "
4.	Atrial Flutter (Flutter, Atrial) 02/01/1988 - "It is concluded that intravenous procainamide effectively augments the efficacy of rapid atrial pacing to convert atrial flutter to sinus rhythm." 02/01/1988 - "Twelve patients with spontaneous atrial flutter that had been present for greater than 24 h were studied to assess the efficacy of atrial pacing, alone and in combination with procainamide, to convert atrial flutter to normal sinus rhythm. " 05/01/1997 - "In conclusion, intravenous procainamide augments the efficacy of atrial pacing to convert atrial flutter to sinus rhythm." 05/01/1997 - "In a prospective, double-blind, randomized, placebocontrolled study we investigated the facilitating influence of intravenous procainamide on conversion of atrial flutter by rapid atrial pacing. " 03/01/2002 - "Pronounced effect of procainamide on clockwise right atrial isthmus conduction compared with counterclockwise conduction: possible mechanism of the greater incidence of common atrial flutter during antiarrhythmic therapy."
5.	Tachycardia (Tachyarrhythmias) 03/01/2000 - "This study was conducted to determine the efficacy of procainamide therapy for rapid rate control of postoperative junctional tachycardia (JT). " 10/01/1981 - "Adverse reactions and efficacy of high-dose procainamide therapy in resistant tachyarrhythmias." 06/01/1991 - "Paired comparisons of efficacy of intravenous and oral procainamide in patients with inducible sustained ventricular tachyarrhythmias." 10/01/1988 - "One hundred six patients with inducible sustained ventricular tachyarrhythmia, whose initial study included short-term drug testing with intravenous procainamide, were evaluated. " 01/01/1983 - "We evaluated 126 patients with inducible sustained ventricular tachyarrhythmias to assess whether the response to procainamide during electrophysiologic study could predict responses to other conventional antiarrhythmic agents and combinations of agents. "

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Related Therapies and Procedures

1.	Intravenous Injections
2.	Ligation
3.	Intravenous Infusions
4.	Drug Therapy (Chemotherapy)
5.	Electric Countershock (Cardioversion)