Bromocriptine: problems with low-dose de novo therapy in Parkinson's disease.

Abstract

Twenty Parkinson's disease patients, who had not yet received levodopa, were treated with low-dose bromocriptine. At a mean daily bromocriptine dose of 13.2 mg, 13 patients (65%) improved and had a 32% reduction in the combined score for tremor rigidity and bradykinesia. Adverse effects were frequent, and 25% of the patients were taken off the drug because of nausea or vomiting. After 30 months follow-up, only three patients continued on bromocriptine alone. Ten patients were eventually maintained on low-dose bromocriptine and levodopa-carbidopa, and a clear synergistic effect of bromocriptine in this drug combination was documented in eight patients. Low-dose bromocriptine does not replace levodopa as initial therapy for Parkinson's disease. The potential long-term benefit of the early use of combined low-dose levodopa-dopamine agonist therapy needs to be further studied.

• Authors: J D Grimes, M R Delgado
• Journal: Clinical neuropharmacology (Clin Neuropharmacol) Vol. 8 Issue 1 Pg. 73-7 ( 1985) ISSN: 0362-5664 [Print] United States
• PMID: 3978651 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Bromocriptine
• Levodopa

Topics

• Adult
• Aged
• Bromocriptine (administration & dosage, adverse effects, therapeutic use)
• Drug Therapy, Combination
• Female
• Humans
• Levodopa (administration & dosage)
• Male
• Middle Aged
• Parkinson Disease (drug therapy)