[DNAse II from phagocytes in the study of the pathogenesis of systemic lupus erythematosus].

Abstract

Activity of acid DNAase (DNAase II) was shown to decrease in neutrophils from peripheric blood of patients with systemic lupus erythematosus as well as in macrophages of liver tissue from mice of the F1(NZB/w) strain during development of the lupus syndrome. Inhibition of the DNAase II activity in phagocytic cells might be among the reasons of accumulation of extracellular highly polymeric DNA in blood of the patients with systemic lupus erythematosus and to play a definite role in pathogenesis of the disease.

• Authors: L I Matul'skaia, V Iu Klimov, T A Riazantseva, G N Pleskovskaia
• Journal: Voprosy meditsinskoi khimii (Vopr Med Khim) 1986 Jan-Feb Vol. 32 Issue 1 Pg. 32-4 ISSN: 0042-8809 [Print] Russia (Federation)
• Vernacular Title: DNKaza II kletok fagotsitiruiushchego riada v izuchenii patogeneza sistemnoĭ krasnoĭ volchanki.
• PMID: 3953009 (Publication Type: English Abstract, Journal Article)

Chemical References

• Endodeoxyribonucleases
• deoxyribonuclease II

Topics

• Animals
• Disease Models, Animal
• Endodeoxyribonucleases (blood)
• Female
• Humans
• Lupus Erythematosus, Systemic (blood, etiology)
• Mice
• Mice, Inbred Strains
• Phagocytes (enzymology)