[Effect of rutin and esculamine on models of aseptic inflammation].

Abstract

It was shown in experiments on rats that intraabdominal administration of silver nitrate solution induces peritonitis and the subplantar administration of histamine, serotonin and prostaglandin E2 leads to an acute paw edema. Preliminary subcutaneous administration of esculamine or rutin inhibited the development of the inflammation. Esculamine proved more active here.

• Authors: P N Aleksandrov, T V Speranskaia, Iu G Bobkov, V A Zagorevskiĭ, D A Zykov
• Journal: Farmakologiia i toksikologiia (Farmakol Toksikol) 1986 Jan-Feb Vol. 49 Issue 1 Pg. 84-6 ISSN: 0014-8318 [Print] Russia (Federation)
• Vernacular Title: Vliianie rutina i éskulamina na nekotorye modeli aspeticheskogo vospaleniia.
• PMID: 3948995 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Anti-Inflammatory Agents
• Flavonoids
• Esculin
• esculamine
• Rutin

Topics

• Animals
• Anti-Inflammatory Agents (therapeutic use)
• Disease Models, Animal
• Drug Evaluation, Preclinical
• Edema (chemically induced, drug therapy)
• Esculin (analogs & derivatives, therapeutic use)
• Flavonoids (therapeutic use)
• Inflammation (chemically induced, drug therapy)
• Male
• Peritonitis (chemically induced, drug therapy)
• Rats
• Rats, Inbred Strains
• Rutin (therapeutic use)