Glanzmann's thrombasthenia associated with gastrointestinal angiodysplasias successfully treated with bevacizumab.

Abstract

Glanzmann's Thrombasthenia (GT) is a rare hemorrhagic condition caused by a platelet surface receptor disorder of the glycoprotein (GP) IIb/IIIa. Symptoms of GT are various forms of hemorrhages, such as purpura, epistaxis and menorrhagia. Gastrointestinal bleeding (GIB) is a rare expression of the condition and may occur due to traumas in the GI tract or as a consequence of gastrointestinal angiodysplasia (GIADs). In this case report, we present a middle-aged woman with recurrent GIB consequent to GIADs with persistent melena and iron deficiency anemia. After several unsuccessful therapeutic interventions, the patient was studied by the hereditary hemorrhagic telangiectasia's (HHT - Osler-Weber-Rendu disease) unit, where she received bevacizumab, showing a complete improvement in symptoms as well as a reduction in her GIADs. This case shows that bevacizumab could be a possible line of treatment for patients with coagulation disorders with GIADs.

• Authors: Agustina Saladino, María L Gonzalez, Fernando A Chuliber, Marcelo M Serra
• Journal: Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis (Blood Coagul Fibrinolysis) Vol. 34 Issue 8 Pg. 545-548 (Dec 01 2023) ISSN: 1473-5733 [Electronic] England
• PMID: 37942747 (Publication Type: Case Reports, Journal Article)
• Copyright: Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.

Chemical References

• Bevacizumab
• Platelet Glycoprotein GPIIb-IIIa Complex

Topics

• Humans
• Middle Aged
• Female
• Thrombasthenia (complications, drug therapy)
• Bevacizumab (therapeutic use)
• Platelet Glycoprotein GPIIb-IIIa Complex
• Menorrhagia (etiology)
• Blood Platelet Disorders
• Gastrointestinal Hemorrhage (etiology, complications)
• Rare Diseases (complications)
• Angiodysplasia (complications, drug therapy)