Abstract | BACKGROUND: RESULTS:
Zofenopril reduced MLN-increased visceral fat to body weight ratio although no changes in systolic blood pressure were recorded. Zofenopril administration resulted in a favorable increase in left ventricle ejection fraction and improvement of diastolic function regardless of ACE2 inhibition, which was associated with increased H2S levels in plasma and heart tissue. Similarly, the acute hypotensive responses induced by acetylcholine, L-NAME (NOsynthase inhibitor) and captopril (ACEI) were comparable after zofenopril administration independently from ACE2 inhibition. Although simultaneous treatment with zofenopril and MLN led to increased thoracic aorta vasorelaxation, zofenopril increased the NO component equally regardless of MLN treatment, which was associated with increased NO-synthase activity in aorta and left ventricle. Moreover, unlike in control rats, the endogenous H2S participated in maintaining of aortic endothelial function in MLN-treated rats and the treatment with zofenopril had no impact on this effect. CONCLUSIONS:
Zofenopril treatment reduced MLN-induced adiposity and improved cardiac function regardless of ACE2 inhibition. Although the concomitant MLN and zofenopril treatment increased thoracic aorta vasorelaxation capacity, zofenopril increased the participation of H2S and NO in the maintenance of endothelial function independently from ACE2 inhibition. Our results confirmed that the beneficial effects of zofenopril were not affected by ACE2 inhibition, moreover, we assume that ACE2 inhibition itself can lead to the activation of cardiovascular compensatory mechanisms associated with Mas receptor, nitrous and sulfide signaling.
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Authors | Sona Cacanyiova, Martina Cebova, Fedor Simko, Tomas Baka, Iveta Bernatova, Michal Kluknavsky, Stefan Zorad, Katarina Krskova, Ezgi Shaman, Anna Zemancikova, Andrej Barta, Basak G Aydemir, Andrea Berenyiova |
Journal | Biological research
(Biol Res)
Vol. 56
Issue 1
Pg. 55
(Oct 25 2023)
ISSN: 0717-6287 [Electronic] England |
PMID | 37875978
(Publication Type: Journal Article)
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Copyright | © 2023. Sociedad de Biologia de Chile. |
Chemical References |
- zofenopril
- Captopril
- 2-(1-carboxy-2-(3-(3,5-dichlorobenzyl)-3H-imidazol-4-yl)ethylamino)-4-methylpentanoic acid
- Angiotensin-Converting Enzyme 2
- Angiotensin-Converting Enzyme Inhibitors
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Topics |
- Humans
- Rats
- Animals
- Captopril
(pharmacology)
- Rats, Inbred SHR
- Angiotensin-Converting Enzyme 2
(pharmacology)
- Pandemics
- Angiotensin-Converting Enzyme Inhibitors
(pharmacology)
- Blood Pressure
- Essential Hypertension
- Cardiovascular System
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