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Characteristic amino acid residues in the growth hormone receptor gene on Mus minutoides underlying dwarfism.

Abstract
The African pygmy mouse ( Mus minutoides ) displays a dwarfism phenotype distinctive from closely related species. This study aimed to investigate the growth hormone receptor (Ghr) gene sequence in M. minutoides . We identified several amino acid variations, including the P469L mutation. Our findings suggest that this mutation affects Ghr protein functionality, decreasing Igf1 expression and contributing to the dwarfism observed in M. minutoides . Further studies utilizing genome editing technology are necessary to elucidate the mechanisms involved in mammalian body size determination.
AuthorsSumito Matsuya, Kaoru Fujino, Hiroyuki Imai, Ken Takeshi Kusakabe, Kiyoshi Kano
JournalmicroPublication biology (MicroPubl Biol) Vol. 2023 ( 2023) ISSN: 2578-9430 [Electronic] United States
PMID37767364 (Publication Type: Journal Article)
CopyrightCopyright: © 2023 by the authors.

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