A NEW HYPOTHESIS IN THE TREATMENT OF RECURRENT GLIOBLASTOMA MULTIFORME (GBM). PART 1: INTRODUCTION.

Abstract

Modern treatment of glioblastoma multiforme (GBM) is based on neurosurgical methods combined with radiotherapy and chemotherapy. The prognosis for patients with GBM is extremely poor. Often, complete removal of the tumor is impossible and it often recurs. Therefore, in addition to standard regimens, modern methods such as modulated electrohyperthermia, monoclonal antibodies and individualised multimodal immunotherapy (IMI) based on vaccines and oncolytic viruses are also used in the treatment of GBM. Radioiodine therapy (RIT) also holds out hope for an effective treatment of this extremely aggressive brain tumor. The expression of the sodium iodide symporter (NIS) gene has been proven to have a positive effect on the treatment of selected cancers. Research confirm the presence of expression of this gene in GBM cells, although only in animal studies. Is it possible and therapeutically effective to treat GBM with RIT without the use of an exogenous NIS gene? The safety of therapy is relevant, as the only more serious adverse effect may be hypothyroidism. The use of RIT requires further clinical studies in patients. Perhaps it is worth revolutionizing GBM therapy to give sufferers a "new life".

• Authors: Agata Czarnywojtek, Paweł Gut, Magdalena Borowska, Kamil Dyrka, Marek Ruchała, Alfio Ferlito
• Journal: Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego (Pol Merkur Lekarski) Vol. 51 Issue 4 Pg. 430-432 ( 2023) ISSN: 1426-9686 [Print] Poland
• PMID: 37756465 (Publication Type: Journal Article)

Chemical References

• Iodine Radioisotopes

Topics

• Animals
• Humans
• Glioblastoma (therapy)
• Iodine Radioisotopes
• Neoplasm Recurrence, Local
• Drug-Related Side Effects and Adverse Reactions
• Hypothyroidism