Kaempferol, a secondary metabolite found in plants, is a naturally occurring
flavonoid displaying significant potential in various
biological activities. The chemical structure of
kaempferol is distinguished by the presence of phenyl rings and four
hydroxyl substituents, which make it an exceptional radical scavenger. Most recently, an increasing number of studies have demonstrated the significance of
kaempferol in the regulation of intestinal function and the mitigation of intestinal
inflammation. The focus of the review will primarily be on its impact in terms of
antioxidant properties,
inflammation, maintenance of intestinal barrier function, and its potential in the treatment of
colorectal cancer and
obesity. Future research endeavors should additionally give priority to investigating the specific dosage and duration of
kaempferol administration for different pathological conditions, while simultaneously conducting deeper investigations into the comprehensible mechanisms of action related to the regulation of
aryl hydrocarbon receptor (AhR). This review intends to present novel evidence supporting the utilization of
kaempferol in the regulation of gut health and the management of associated diseases.