Feline osteochondromatosis in a 12-year-old feline leukaemia virus-negative cat.

Abstract

Feline osteochondromatosis is a spontaneous osteocartilaginous exostosis associated with feline leukaemia virus (FeLV) infection or due to a frameshift variant in the exostosin glycosyltransferase 1 (EXT1) gene. Osteochondromatosis was diagnosed in an indoor-only, 12-year-old, neutered female, Russian Blue cat. Radiographs revealed bilateral calcified proliferations in the elbow, costochondral and sternochondral joints, which distorted the normal skeletal structure. Grossly, the proliferated joints presented with consistent, rounded masses, causing complete ankylosis. The main histopathological finding was an osteocartilaginous proliferation composed of multiple irregular islands of well-differentiated hyaline cartilage surrounded and delimited by osteoid tissue. Immunohistochemistry of the osteochondromas, bone marrow and mediastinal lymph nodes, using a primary anti-FeLV gp70 antibody, and FeLV proviral DNA real-time polymerase chain reaction on bone marrow were negative. Sequencing of exon 6 of the EXT1 gene was performed and nucleotide BLAST analysis demonstrated the absence of a frameshift variant. This study reports the only case of spontaneous feline osteochondromatosis in an animal more than 10 years old.

• Authors: Álex Gómez, Ana Rodríguez-Largo, Estela Pérez, Natalia Calvo-Sánchez, Sarah Loomans, Koen Chiers, Luis Monteagudo, Lluís Luján, Marta Pérez
• Journal: Journal of comparative pathology (J Comp Pathol) Vol. 205 Pg. 24-26 (Aug 2023) ISSN: 1532-3129 [Electronic] England
• PMID: 37597496 (Publication Type: Journal Article)
• Copyright: Copyright © 2023 The Author(s). Published by Elsevier Ltd.. All rights reserved.

Topics

• Female
• Cats
• Animals
• Leukemia Virus, Feline
• Osteochondromatosis (veterinary)
• Leukemia, Feline
• Exons
• Ankylosis (veterinary)
• Cat Diseases