In the current study,
hydrogels for the controlled release of
diclofenac sodium were synthesized from
graphene oxide-reinforced
guar gum and poly (N-vinyl-2-pyrrolidone) using the
Solution Casting Technique. Varying concentrations of 3-Glycidyloxypropyl
trimethoxysilane (GLYMO) were employed for the crosslinking of
hydrogels. Further, the characterization of
hydrogels was carried out using different techniques such as Fourier Transform Infrared Spectroscopy (FTIR), X-ray diffraction, thermal analysis and scanning electron microscope. The FTIR investigations reveals particular functionalities and development of
hydrogel interfaces. While thermal analysis prophesied that, improvement in forces among
hydrogel components is directly proportional to the GLYMO concentration. In-vitro biodegradation test and cell viability assay against HEK-293 cell lines confirmed their biodegradable and biocompatible nature. GPG-32 demonstrated maximum antibacterial activity against P.aeruginosa and E.coli strains. The maximum swelling 2001 % and 1814 % in distilled water were recorded for
GPG (control) and GPG-8 respectively that obeyed Fick's law.
Hydrogels displayed high swelling responses at pH 6 in
buffer and non-
buffer solutions. In 2.5 h, 88.7 %
diclofenac sodium was released which was determined by UV visible spectrophotometer. In conclusion,
guar gum-based non-toxic, biocompatible and biodegradable
hydrogels would be a model platform for targeting
inflammation and pains. Furthermore, improved mechanical and viscoelastic behavior of
hydrogels could also be explored for making
drug loaded dressings for wound healing applications.