Association between remnant cholesterol and subclinical carotid atherosclerosis among Chinese general population in health examination.

Abstract

OBJECTIVE:

Remnant cholesterol (RC) was associated with carotid atherosclerosis in patients with clinical settings. But the value of RC as a risk management indicator for subclinical carotid atherosclerosis in health examination has not been fully determined.

METHODS:

This was a real-world, cross-sectional study including 12317 Chinese general population. Carotid intima-media thickness (CIMT) and carotid atherosclerotic plaque (CAP) were assessed by ultrasound. RC was calculated by total cholesterol minus low density lipoprotein-cholesterol (LDL-C) minus high density lipoprotein-cholesterol (HDL-C).Carotid atherosclerosis (CAS) was defined as a composite of increased CIMT and CAP. Multivariable logistic regression models were used to investigate the association of RC and CAS, increased CIMT and CAP.

RESULTS:

Among 12317 participants (mean age: 51.21±13.76 years; 8303 men and 4014 women), the prevalence of CAS and increased CIMT was higher in participants with higher RC levels (P for trend<0.01). After multivariable adjustment, the highest quartile of RC was significantly associated with higher risk of CAS (OR: 1.45 95%CI: 1.26-1.67) and increased CIMT (OR: 1.48 95%CI: 1.29-1.71) with the lowest quartile of RC as reference. And the relationships remained significant even after adjustment of LDL-C and HDL-C. Every 1-SD increase of RC level was positively associated with 17% risk increment for CAS (6-30%) and 20% risk increment for increased CIMT (8-34%).

CONCLUSION:

Elevated serum RC levels were significantly associated with CAS and increased CIMT among Chinese general population, independent of LDL-C and HDL-C. RC evaluation could be applied for the risk management of early stage of subclinical carotid atherosclerosis in health examination.

• Authors: Nimei Zeng, Yu'e Shen, Yuan Li, Yun Wang
• Journal: Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association (J Stroke Cerebrovasc Dis) Vol. 32 Issue 8 Pg. 107234 (Aug 2023) ISSN: 1532-8511 [Electronic] United States
• PMID: 37392486 (Publication Type: Journal Article)
• Copyright: Copyright © 2023 Elsevier Inc. All rights reserved.

Chemical References

• Cholesterol, LDL
• Cholesterol
• Cholesterol, HDL

Topics

• Male
• Humans
• Female
• Adult
• Middle Aged
• Aged
• Cholesterol, LDL
• Carotid Intima-Media Thickness
• Cross-Sectional Studies
• East Asian People
• Carotid Artery Diseases (diagnostic imaging, epidemiology)
• Cholesterol
• Plaque, Atherosclerotic
• Risk Factors
• Cholesterol, HDL