Abstract |
Ampullary carcinomas are uncommon malignant tumours of the digestive system, they usually are adenocarcinomas presenting histologically as three types: intestinal, pancreaticobiliary and mixed. β- catenin is a multifunctional protein involved in physiological homoeostasis and intracellular adhesion. Abnormal nuclear accumulation of β- catenin has been described in many malignancies such as colon, breast, liver and others. The relationships between the immunohistochemical expression of β- catenin and the subtype, the grade and the stage of ampullary carcinoma are studied. Material and methods: A cross-sectional retrospective study was done on 25 formalin-fixed paraffin-embedded blocks of ampullary carcinoma: Cases were collected from the archives of the pathology department in the Gastroenterology and hepatology teaching hospital, medical city/ Baghdad from January 2019 to March 2022. The data of the patients and the characteristics of the tumour were derived from the pathological reports; additional sections from the block were stained with β- catenin immunohistochemically. Results: 25 paraffin blocks from patients with ampullary carcinoma (12 males, 13 females) were included in the study. 64% of the cases are classified as pancreaticobiliary, 20% as mixed, 12% as intestinal and 4% as adenosquamous type. Eighty-four percent of the cases are moderately differentiated, and the remaining is poorly differentiated. Most cases show strong β- catenin membranous staining and 80% express 3+ staining of cytoplasmic β- catenin. Regarding nuclear β- catenin staining, 56% has negative staining. Conclusion: No significant association was found between the cytoplasmic and the nuclear expression of β- catenin and the tumour type, size and lymph node status. The grade of the tumour showed a significant correlation with the cytoplasmic expression; while, no correlation was noted with the nuclear expression. This study results do not support the use of beta-catenin as a diagnostic marker or prognostic marker in ampullary cancers.
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Authors | Sazan Abdulwahab Mirza, Mohammed N Hilmi, Azza N Al Jaleeli |
Journal | Annals of medicine and surgery (2012)
(Ann Med Surg (Lond))
Vol. 85
Issue 6
Pg. 2512-2517
(Jun 2023)
ISSN: 2049-0801 [Print] England |
PMID | 37363570
(Publication Type: Journal Article)
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Copyright | Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc. |