Objective.
Nonalcoholic fatty liver disease (
NAFLD) is a spectrum of
liver diseases characterized by the presence of ectopic fat in the liver and steatosis, which cannot be explained by alcohol consumption. The association between
NAFLD and
type 2 diabetes mellitus (T2DM) is well established. As
liver fibrosis progresses in a patient with
NAFLD,
insulin resistance (IR) increases and may worsen diabetes control. The
aspartate aminotransferase platelet ratio index (APRI) score is a simple and inexpensive bedside marker that can detect
liver fibrosis and
cirrhosis. Several studies have shown an association between APRI and
NAFLD. However, there is a gap in correlation with IR in patients with diabetes. In this study, we sought to correlate IR and
NAFLD in diabetes using the APRI score. Methods. This observational hospital-based cross-sectional study was conducted in the Department of General Medicine, one of the tertiary care hospitals in North India, from February 2019 to July 2020. A total of 70 patients were taken for the study. Patients with T2DM, aged >30 years, who had no history of alcohol use and who had or were newly diagnosed with
NAFLD were enrolled in the study. Results. Significant differences in mean HbAc1, AST, serum
insulin, APRI score and homeo-static model assessment-2 (HOMA2) IR between
NAFLD grade 1, grade 2, and grade 3 groups were found. Pearson correlation between APRI score and HOMA2 IR total values revealed a significant positive correlation between them. Conclusions. The data of the present study indicate that the APRI score can be used to assess the IR degree and provide important information for improving
glycemic control in T2DM patients with
NAFLD.