WHSC1 is involved in DNA damage, cellular senescence and immune response in hepatocellular carcinoma progression.

Abstract

Wolf-Hirschhorn syndrome candidate 1 (WHSC1) is a transcriptional regulatory protein that encodes a histone methyltransferase to control H3K36me2 modification. WHSC1 was upregulated and associated with poor prognosis in HCC. The elevated WHSC1 likely due to the alterations of DNA methylation or RNA modification. WHSC1 perhaps form a chromatin cross talk with H3K27me3 and DNA methylation to regulate transcription factors expression in HCC. Functional analysis indicated that WHSC1 was involved in DNA damage repair, cell cycle, cellular senescence and immune regulations. Furthermore, WHSC1 was associated with the infiltrating levels of B cell, CD4+, Tregs and macrophage cells. Therefore, our findings suggested that WHSC1 might function as a promotor regulator to affect the development and progression of HCC. Thus, WHSC1 could be a potential biomarker in predicting the prognosis and therapeutic target for patients with HCC.

• Authors: Jia Yan, Ming Yang Zhang, Jing Lin, Ke Xin Li, Zhi Min Zhao, Yu Min Gao, Xiu Ling Deng, Chang Shan Wang, Hai Sheng Wang
• Journal: Journal of cellular and molecular medicine (J Cell Mol Med) Vol. 27 Issue 10 Pg. 1436-1441 (05 2023) ISSN: 1582-4934 [Electronic] England
• PMID: 37073435 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2023 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd.

Chemical References

• Histones
• Repressor Proteins
• Transcription Factors
• NSD2 protein, human

Topics

• Humans
• Carcinoma, Hepatocellular (genetics)
• Cellular Senescence (genetics)
• DNA Damage (genetics)
• Histones (genetics, metabolism)
• Immunity
• Liver Neoplasms (genetics)
• Repressor Proteins (genetics)
• Transcription Factors (metabolism)