Abstract | PURPOSE OF REVIEW: The present review summarizes findings of recent studies examining the epidemiology, pathophysiology, and treatment of type 4 renal tubular acidosis (RTA) and uric acid nephrolithiasis, two conditions characterized by an abnormally acidic urine. RECENT FINDINGS: SUMMARY: Type 4 RTA and uric acid nephrolithiasis share several epidemiological, clinical, and biochemical features. Although both conditions may be manifestations of diabetes mellitus and thus have a large at-risk population, the means to the shared biochemical finding of overly acidic urine are different. This difference in pathophysiology may explain the dissimilarity in the prevalence of kidney stone formation.
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Authors | Emmanuel A Adomako, Naim M Maalouf |
Journal | Current opinion in nephrology and hypertension
(Curr Opin Nephrol Hypertens)
Vol. 32
Issue 2
Pg. 145-152
(Mar 01 2023)
ISSN: 1473-6543 [Electronic] England |
PMID | 36683539
(Publication Type: Review, Journal Article)
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Copyright | Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved. |
Chemical References |
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Topics |
- Humans
- Uric Acid
- Diabetes Mellitus, Type 2
(complications, epidemiology)
- Acidosis, Renal Tubular
(epidemiology, complications)
- Hyperkalemia
- Hydrogen-Ion Concentration
- Kidney Calculi
(complications)
- Nephrolithiasis
(epidemiology)
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