Abstract | BACKGROUND: CLINICAL CASE: A 60-year-old man visited a municipal hospital with the chief complaint of fatigue. He was found to have hemolytic anemia and icterus with increased cold agglutination and was diagnosed with CAD. Malignant lymphoma was suspected as the underlying disease; however, no clear underlying disease was identified. Hemolytic anemia progressed during the subsequent winter seasons, and he was treated with temperature control, warming, and weekly blood transfusions. However, despite the blood transfusions, his hemoglobin level did not improve during the summer 2 years after diagnosis, and his previously observed splenomegaly had progressed. He was referred to our department, and a splenectomy was performed to diagnose any occult malignant lymphoma and improve the refractory hemolytic anemia. Because histopathological examination revealed no evidence of malignant lymphoma, a diagnosis of primary CAD was made. The hemolytic anemia improved, and no blood transfusion was required after splenectomy. CONCLUSIONS:
Splenectomy significantly improved the patient's refractory hemolytic anemia due to primary CAD. Thus, it may be an effective treatment option in such cases, although further cases and studies are required to evaluate the effects of splenectomy.
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Authors | Shuji Okamoto, Takeshi Urade, Kimikazu Yakushijin, Masahiro Kido, Kaori Kuramitsu, Shohei Komatsu, Hidetoshi Gon, Hironori Yamashita, Sachiyo Shirakawa, Daisuke Tsugawa, Sachio Terai, Hiroaki Yanagimoto, Hirochika Toyama, Takumi Fukumoto |
Journal | The Kobe journal of medical sciences
(Kobe J Med Sci)
Vol. 68
Issue 1
Pg. E30-E34
(Jan 11 2023)
ISSN: 1883-0498 [Electronic] Japan |
PMID | 36647084
(Publication Type: Review, Case Reports, Journal Article)
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Topics |
- Male
- Humans
- Middle Aged
- Anemia, Hemolytic, Autoimmune
(complications, surgery, diagnosis)
- Splenectomy
- Anemia, Hemolytic
- Hemolysis
- Lymphoma
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