Abstract | BACKGROUND: OBJECTIVE: To evaluate the potential benefits and risks of the use of LMWH for prevention of pregnancy-related VTE and obstetrical complications in the first pregnancy after a previous VTE. METHODS: This retrospective cohort study includes fertile women referred to the Thrombosis Center from January 2000 to September 2018 for a thrombophilia work-up, after having had at least one previous VTE and one pregnancy thereafter. Data on pregnancy-related recurrent VTE, pregnancy outcomes and the use of LMWH were collected. RESULTS: Among 208 women, no thrombosis or major bleeding was recorded in 138 pregnancies conducted with LMWH, whereas 10 VTE (14%) were recorded in 70 pregnancies conducted without. Nine women (90%) with recurrent VTE had had a previous hormone-related event. The incidence of miscarriage was lower in pregnancies with LMWH than in those without (11% vs. 26%, relative risk 0.4, 95% confidence interval: 0.2-0.8), whereas late obstetrical complications and terminations were similar in the two groups. The prevalence of terminations was doubled in women with thrombophilia (12%) than in those without (6%). CONCLUSIONS:
LMWH prophylaxis during pregnancy appears to be effective and safe for the prevention of recurrent VTE and may reduce the incidence of miscarriage.
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Authors | Maria Abbattista, Marco Capecchi, Francesca Gianniello, Andrea Artoni, Paolo Bucciarelli, Alessandro Ciavarella, Flora Peyvandi, Ida Martinelli |
Journal | Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis
(Blood Coagul Fibrinolysis)
Vol. 34
Issue 2
Pg. 111-117
(Mar 01 2023)
ISSN: 1473-5733 [Electronic] England |
PMID | 36598379
(Publication Type: Journal Article)
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Copyright | Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved. |
Chemical References |
- Heparin, Low-Molecular-Weight
- Anticoagulants
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Topics |
- Pregnancy
- Female
- Humans
- Heparin, Low-Molecular-Weight
(therapeutic use)
- Venous Thromboembolism
(drug therapy)
- Retrospective Studies
- Abortion, Spontaneous
- Thrombosis
(drug therapy)
- Thrombophilia
(complications, drug therapy)
- Anticoagulants
(therapeutic use)
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