Determining if gastrointestinal (GI)
hormone response to food intake differs between individuals with, and without,
obesity may improve our understanding of
obesity pathophysiology. A systematic review and meta-analysis of studies assessing the concentrations of GI
hormones, as well as appetite ratings, following a test meal, in individuals with and without
obesity was undertaken. Systematic searches were conducted in the databases MEDLINE, Embase, Cochrane Library, PsycINFO, Web of Science, and ClinicalTrials.gov. A total of 7514 unique articles were retrieved, 115 included in the systematic review, and 70 in the meta-analysis. The meta-analysis compared estimated standardized mean difference in GI
hormones' concentration, as well as appetite ratings, between individuals with and without
obesity. Basal and postprandial total
ghrelin concentrations were lower in individuals with
obesity compared with controls, and this was reflected by lower postprandial hunger ratings in the former. Individuals with
obesity had a lower postprandial concentration of total
peptide YY compared with controls, but no significant differences were found for
glucagon-like peptide 1,
cholecystokinin, or other appetite ratings. A large methodological and statistical heterogeneity among studies was found. More comprehensive studies are needed to understand if the differences observed are a cause or a consequence of
obesity.