Cholecystokinin (Pancreozymin)

A peptide, of about 33 amino acids, secreted by the upper INTESTINAL MUCOSA and also found in the central nervous system. It causes gallbladder contraction, release of pancreatic exocrine (or digestive) enzymes, and affects other gastrointestinal functions. Cholecystokinin may be the mediator of satiety.

Also Known As:

Networked: 1808 relevant articles (30 outcomes, 206 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Rehfeld, Jens F: 8 articles (09/2013 - 01/2002)
2.	Smith, Jill P: 7 articles (03/2015 - 12/2002)
3.	Konturek, S J: 7 articles (03/2007 - 02/2001)
4.	Miller, Laurence J: 6 articles (09/2015 - 02/2002)
5.	Horowitz, Michael: 6 articles (08/2013 - 01/2006)
6.	Rehfeld, J F: 6 articles (05/2010 - 06/2000)
7.	Maina, Theodosia: 5 articles (11/2015 - 10/2005)
8.	de Jong, Marion: 5 articles (11/2015 - 07/2009)
9.	Feinle-Bisset, Christine: 5 articles (02/2014 - 01/2007)
10.	Lai, Josephine: 5 articles (01/2012 - 01/2005)

Related Diseases

1.	Pain (Aches) 02/01/1995 - "Recent studies have suggested that cholecystokinin may have a role in modulating the effects of the endogenous opioid system in physiological functions such as thermoregulation and pain control. " 12/01/1978 - "In this study, a positive cholecystokinin cholecystogram (CCK-GB) was defined as both reproduction of the patient's biliary tract-type pain plus one or more of various roentgen abnormalities. " 09/01/2015 - "Vagal afferent-dependent cholecystokinin modulation of visceral pain requires central amygdala NMDA-NR2B receptors in rats." 12/01/2013 - "EF, body mass index percentile (BMI %), and pain with cholecystokinin (CCK) were not predictive of ongoing pain at either follow-up periods. " 12/01/2013 - "All were symptomatic with an ejection fraction (EF) <35 % or pain with cholecystokinin administration. "
2.	Exocrine Pancreatic Insufficiency 06/01/1989 - "The present study was undertaken to examine the intestinal phase of cholecystokinin (CCK) secretion and gall bladder contraction in patients with severe pancreatic insufficiency. " 01/01/1997 - "A failure of cholecystokinin (CCK) release after a meal has been shown among patients with exocrine pancreatic insufficiency. " 06/01/1989 - "Effect of pancreatic enzyme supplementation on postprandial plasma cholecystokinin secretion in patients with pancreatic insufficiency." 12/01/1984 - "It has been claimed that plasma cholecystokinin (CCK) concentrations are raised in patients with pancreatic insufficiency. " 12/01/1984 - "Plasma cholecystokinin concentrations in patients with pancreatic insufficiency measured by sequence-specific radioimmunoassays."
3.	Gallstones (Gallstone) 04/01/1990 - "The prevalence of gallstones was: 1-mo-old, control 0 out of 16, cholecystokinin 1 out of 15; 1-yr-old, control 3 out of 14, cholecystokinin 5 out of 16; 3-yr-old, control 10 out of 11, cholecystokinin 3 out of 8. Gallstone formation was significantly greater in 3-yr-old controls than in the two younger control groups, and cholecystokinin treatment significantly reduced the incidence of gallstones to near the level seen in younger guinea pigs. " 08/01/1994 - "Studies in humans and rodents indicate that gallstone development may be prevented by inhibiting gallbladder mucus hypersecretion with non-steroidal anti-inflammatory drugs or by preventing stasis of gallbladder bile with administration of cholecystokinin. " 04/01/1990 - "The purpose of this study was to evaluate the effect of age and the role of cholecystokinin therapy on gallstone formation in guinea pigs. " 03/01/1989 - "[An experimental study on preventing gallstone formation by exogenous cholecystokinin]." 03/01/1989 - "The present study was undertaken to determine whether gallbladder emptying, endogenous cholecystokinin (CCK) secretion, or their interrelation is altered in patients with gallstones. "
4.	Chronic Pancreatitis 09/01/2009 - "Cholecystokinin-stimulated endoscopic pancreatic function testing has low specificity for diagnosis of early chronic pancreatitis, likely because of correctable technical limitations or failure to exclude confounding diseases. " 05/01/2000 - "The cholecystokinin postprandial plasma levels were significantly higher in all patients with chronic pancreatitis when compared with healthy individuals, which suggests the role of cholecystokinin in the feedback control of pancreatic secretion." 05/01/2000 - "The cholecystokinin postprandial plasma levels were significantly higher in patients with chronic pancreatitis when compared with those of healthy individuals (P < 0.01). " 05/01/2000 - "The presence of such a feedback mechanism in chronic pancreatitis patients with exocrine enzyme deficiency possibly leads to an increase in cholecystokinin plasma levels. " 08/01/1999 - "Cholecystokinin (CCK) secretion may be affected in patients with chronic pancreatitis (CP), but little is known on the effect of pancreatic surgery on CCK secretion. "
5.	Body Weight (Weight, Body) 10/01/2001 - "The objective of this study was to examine the effects of 10% food restriction on body weight, plasma cholecystokinin (CCK) levels, and exocrine pancreatic function in male Sprague-Dawley rats. " 02/01/2015 - "Analyses were conducted to assess the in vivo digestibility, food intake, body weight evolution and cholecystokinin levels in Wistar rats. " 01/01/2015 - "Cholecystokinin is implicated in digestion, appetite control and body weight regulation, and may play a role in several digestive disorders. " 03/01/2013 - "Cholecystokinin (CCK) is a hypothetical controller for suckling and infancy body weight, although the underlying mechanisms remain unclear. " 12/01/2009 - "Thylakoids suppress appetite by increasing cholecystokinin resulting in lower food intake and body weight in high-fat fed mice."

Related Drugs and Biologics

1.	Secretin
2.	Hormones
3.	Cholecystokinin (Pancreozymin)
4.	Cholesterol
5.	Gastrins
6.	Somatostatin (Somatotropin Release-Inhibiting Factor)
7.	Morphine (MS Contin)
8.	Proglumide (Milid)
9.	Neuropeptides
10.	Neuropeptide Y

Related Therapies and Procedures

1.	Cholecystectomy
2.	Parenteral Nutrition
3.	Analgesia
4.	Intravenous Infusions
5.	Injections