Role of TRPV1 in respiratory disease and association with traditional Chinese medicine: A literature review.

Abstract

Transient receptor potential vanilloid type 1 (TRPV1), involved in multiple pathophysiological processes including inflammation, is a thermally activated, non-selective cation channel. It has been identified that TRPV1 is highly involved in some common respiratory diseases including allergic rhinitis, asthma, chronic obstructive pulmonary disease, and pulmonary infection by participating in neurogenic and immunogenic inflammation, sensitization, and oxidative stress. In recent years, the hypothesis of transient receptor potential (TRP) has been introduced in studies on the theory of five flavors and four properties of Chinese medicinal. However, the hypothesis is undetermined due to the multi-component and multi-target characteristics of Chinese medicinal. This study describes the relations between TRPV1 and four types of respiratory diseases based on the literature in recent five years. In the meantime, the therapeutic effect of Chinese medicinal by intervening TRPV1 was reviewed, in an attempt to provide certain evidence for future studies on the medicinal property-effect relationship, mechanism of drug action, the syndrome differentiation in traditional Chinese medicine (TCM) for respiratory diseases and to help for new drug development.

• Authors: Meiping Liu, Xinhua Jia, Huaman Liu, Rong He, Xinyue Zhang, Yumeng Shao
• Journal: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie (Biomed Pharmacother) Vol. 155 Pg. 113676 (Nov 2022) ISSN: 1950-6007 [Electronic] France
• PMID: 36088856 (Publication Type: Journal Article, Review)
• Copyright: Copyright © 2022 The Authors. Published by Elsevier Masson SAS.. All rights reserved.

Chemical References

• TRPV Cation Channels
• TRPV1 protein, human

Topics

• Humans
• TRPV Cation Channels
• Medicine, Chinese Traditional
• Respiratory Tract Diseases (drug therapy)
• Asthma (drug therapy)
• Inflammation