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Protective effects of Bacillus licheniformis against Citrobacter freundii infection in Chinese mitten crab Eriocheir sinensis.

Abstract
Citrobacter freundii is an important bacterial pathogen that causes serious diseases in Chinese mitten crab Eriocheir sinensis. However, scarce information is available on the use of Bacillus licheniformis to protect E. sinensis from C. freundii infection by improving the immunity, antioxidant ability and intestinal flora. In the present study, a 60-day feeding trial was conducted to examine the potential effects of dietary supplementation with antagonistic B. licheniformis on the non-specific immunity, antioxidant capability, intestinal flora and resistance of E. sinensis to C. freundii infection. The results indicated that dietary supplementation of B. licheniformis could boost non-specific immunity and antioxidant capability of E. sinensis in a significant dose-dependent manner respectively by increasing serum lysozyme, superoxide dismutase, alkaline phosphatase, and catalase activities and hepatopancreatic superoxide dismutase, catalase, acid phosphatase activities. In addition, crabs fed diets with B. licheniformis displayed increased composition and diversity of the intestinal flora, and exhibited significant defense against C. freundii infection with the relative percentage survivals ranging from 61.9% to 100.0% for seven days. To our knowledge, this is the first report of antagonistic B. licheniformis as a supplement in Chinese mitten crab feed to effectively resist C. freundii infection by improving the non-specific immunity, antioxidant status and intestinal flora.
AuthorsHaipeng Cao, Xiaodong Huang, Ying Gu, Xurui Zheng, La Xu, Chunlei Gai
JournalJournal of invertebrate pathology (J Invertebr Pathol) Vol. 193 Pg. 107805 (09 2022) ISSN: 1096-0805 [Electronic] United States
PMID35921916 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2022 Elsevier Inc. All rights reserved.
Chemical References
  • Antioxidants
  • Catalase
  • Superoxide Dismutase
Topics
  • Animal Feed (analysis)
  • Animals
  • Antioxidants (pharmacology)
  • Bacillus licheniformis
  • Brachyura
  • Catalase (pharmacology)
  • China
  • Citrobacter freundii
  • Immunity, Innate
  • Superoxide Dismutase

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