Muramidase (Lysozyme)

A basic enzyme that is present in saliva, tears, egg white, and many animal fluids. It functions as an antibacterial agent. The enzyme catalyzes the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrin. EC 3.2.1.17.

Also Known As:

Networked: 2640 relevant articles (83 outcomes, 228 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Dobson, Christopher M: 16 articles (10/2013 - 08/2003)
2.	Dumoulin, Mireille: 12 articles (10/2013 - 08/2003)
3.	Kumita, Janet R: 12 articles (10/2013 - 09/2005)
4.	Jacobs, Hans: 11 articles (03/2014 - 03/2003)
5.	Mink, Steven N: 11 articles (03/2014 - 03/2003)
6.	Rubio, Carlos A: 10 articles (12/2015 - 05/2008)
7.	Cheng, Zhao-Qin: 10 articles (03/2014 - 01/2004)
8.	Light, R Bruce: 8 articles (09/2009 - 03/2003)
9.	Liu, Yang: 7 articles (11/2015 - 01/2010)
10.	Kasian, Krika: 7 articles (03/2014 - 11/2007)

Related Diseases

1.	Infection 07/01/1992 - "One of the important non-specific defensive factors of the organism participating in the protection against infections is lysozyme. " 07/07/2000 - "The pgdA gene may contribute to pneumococcal virulence by providing protection against host lysozyme, which is known to accumulate in high concentrations at infection sites." 11/01/2013 - "Here, we employ a murine model to show that this engineered enzyme is superior to wild-type human lysozyme as a treatment for mucoid Pseudomonas aeruginosa lung infections. " 09/01/2002 - "Since lysozyme is the only known pulmonary enzyme that can lyse bacterial cell wall PGN, other innate immune molecules appear to be responsible for signalling and enhancing the clearance of GPB infection from the lung. " 09/01/1981 - "In all patients, lysozyme returned to normal when the infection cleared. "
2.	Carcinoma (Carcinomatosis) 07/01/1982 - "Lysozyme in human gastric carcinoma: a retrospective immunohistochemical study." 11/01/2003 - "Recently, it was demonstrated that patients having lysozyme-secreting breast carcinomas were associated with a favorable prognosis. " 09/01/2001 - "Lysozyme expression by breast carcinomas, correlation with clinicopathologic parameters, and prognostic significance." 01/01/2000 - "Lysozyme and protein were also measured in the biological fluids derived from human bronchial preparations obtained from patients who had undergone surgery for lung carcinoma. " 08/18/1994 - "Oligomers made of Asp-52-esterified lysozyme or native one showed agglutination for human, mouse, rat and chicken erythrocytes, and also for Hep G2 cells (liver carcinoma-derived cell line) [1] not weaker than wheat germ agglutinin (WGA). "
3.	Bacterial Infections (Bacterial Infection) 06/01/2011 - "Lysozyme is an enzyme that is essential for protection against bacterial infections. " 03/01/2002 - "Rhizosphere bacterial communities of two transgenic potato lines which produce T4 lysozyme for protection against bacterial infections were analyzed in comparison to communities of wild-type plants and transgenic controls not harboring the lysozyme gene. " 08/01/1998 - "The salivary gland lysozyme may be involved in protection against bacterial infection in the anterior portion of the mosquito digestive tract." 11/01/2015 - "Lysozyme protects us from the ever-present danger of bacterial infection and binds to bacterial lipopolysaccharide (LPS) with high affinity. " 10/01/2015 - "Lysozyme protects us from the ever-present danger of bacterial infection and binds to bacterial lipopolysaccharide (LPS) with a high affinity. "
4.	Neoplasms (Cancer) 01/01/2008 - "Immunohistochemical studies show the tumor cells to be positive for CD45 (LCA), CD45RO, CD4, CD68, and lysozyme; and negative for all other T-, B-, macrophage, follicular dendritic- and hematopoietic-cell markers. " 01/01/2008 - "Taken together, our studies clearly show that the newly identified marine lysozyme is a potent antitumor molecule, which may inhibit tumor growth and inhibit angiogenesis. " 10/01/2000 - "This study was undertaken for determination of lysozyme concentration in urine of 32 oesophageal cancer patients to evaluate if this enzyme activity changes in oesophageal cancer used for detection of this cancer especially in its early stage. " 09/01/2000 - "A panel of immunohistochemical studies revealed that the majority of tumors were immunoreactive for at least two markers of vascular differentiation (CD34, FVIIIRAg, VEGFR3, and CD31) and at least one marker of histiocytic differentiation (CD68 and/or lysozyme). " 01/01/1998 - "The aim of the study was to determine the effect of renal tumor embolization on nonspecific immunity by evaluating lysozyme activity and leucocytosis in 45 patients and 40 healthy people. "
5.	Pneumonia (Pneumonitis) 03/01/2010 - "Aerosolized recombinant human lysozyme ameliorates Pseudomonas aeruginosa-induced pneumonia in hamsters." 11/01/2011 - "Previous studies from this laboratory have shown that aerosolized recombinant human lysozyme (rhLZ) mitigates Pseudomonas aeruginosa (PA)-induced pneumonia. " 01/01/2002 - "Our clinic-laboratory studies have revealed a sharp deficit of endogenic lysozyme in the blood serum of leukemic patients and extremely low lysozyme content in lavage liquid, from leukemic patients, with pneumonia. " 01/01/2001 - "Correspondingly, the values of neutrophilic infiltration, macrophageal phagocytic and microbicidal activities and the levels of lysozyme and sIg-A may be serve as markers of the lingering course of acute pneumonias." 01/01/1991 - "[The dynamic lysozyme activity of the bronchial secretion in children in the acute period of pneumonia]."

Related Drugs and Biologics

1.	Lactoferrin
2.	Glucuronidase
3.	Proteins (Proteins, Gene)
4.	Enzymes
5.	Peroxidase (Myeloperoxidase)
6.	Complement System Proteins (Complement)
7.	Anti-Bacterial Agents (Antibiotics)
8.	Antinuclear Antibodies
9.	Immunoglobulin A (IgA)
10.	Immunoglobulins (Immunoglobulin)

Related Therapies and Procedures

1.	Oral Administration
2.	Microspheres (Microsphere)
3.	Laser Therapy (Surgery, Laser)
4.	Fluid Therapy (Oral Rehydration Therapy)
5.	Drug Therapy (Chemotherapy)