TRPC1 correlates with poor tumor features, radiotherapy efficacy and survival in tongue squamous cell carcinoma.

Abstract

Aim: The present study aimed to explore the clinical association of TRPC1 with tongue squamous cell carcinoma (TSCC) tumor features and prognosis. Methods: A total of 246 TSCC patients who underwent surgical resection were retrospectively analyzed, and their tissue specimens were acquired for TRPC1 protein and mRNA detection. Results: TRPC1 protein immunohistochemistry score and mRNA expression were of good value in differentiating TSCC tissue from tumor-adjacent tissue and were positively correlated with pathological grade and tumor node metastasis stage. A high TRPC1 protein score was negatively correlated with overall survival, and this correlation was dramatically obvious in patients who received adjuvant radiotherapy. Conclusion: TRPC1 correlates with poor tumor features and unfavorable survival in TSCC patients.

• Authors: Guang Shi, Weiwei Cui, Yingqi Liu, Lei Li, Ying Sun, Xueqiang Zhang, Jianjun Jiao
• Journal: Biomarkers in medicine (Biomark Med) Vol. 16 Issue 11 Pg. 867-877 (08 2022) ISSN: 1752-0371 [Electronic] England
• PMID: 35833829 (Publication Type: Journal Article)

Chemical References

• RNA, Messenger

Topics

• Carcinoma, Squamous Cell (genetics, metabolism, radiotherapy)
• Humans
• Prognosis
• RNA, Messenger
• Retrospective Studies
• Tongue (metabolism, pathology)
• Tongue Neoplasms (genetics, metabolism, radiotherapy)