Furostanol saponins from Asparagus racemosus as potential hypoglycemic agents.
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| Abstract |
Bioactivity guided phytochemical investigation led to isolation of six undescribed furostanol saponins, furoasparoside A-F along with five known compounds, gallic acid, methyl gallate, quercetin-3-O-β-glucopyranoside, liquiritigenin 4׳-O-β-apiofuranosyl-(1 → 2)-β-glucopyranoside and β-glucogallin for the first time from the roots of Asparagus racemosus. Isolated saponins were screened for their antidiabetic potential in L6-GLUT4myc myotubes in vitro followed by an in vivo evaluation in streptozocin-induced diabetic rats and db/db mice. Furoasparoside E produced a notable decrease in the postprandial blood glucose profile, in leptin receptor-deficient db/db mice, type 2 diabetes model. The effect of furoasparoside E on GLUT4 translocation was found to be mediated by the AMPK-dependent signaling pathway in L6-GLUT4myc myotubes. Moreover, it emerged as a stable plant metabolite with higher bioavailability and efficacy in in vivo pharmacokinetic studies. Therefore, these studies indicated that furoasparoside E may serve as a propitious lead for the management of type 2 diabetes and its secondary complications from natural source.
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| Authors | Alka Raj Pandey, Shadab Ahmad, Suriya Pratap Singh, Anjali Mishra, Amol Chhatrapati Bisen, Gaurav Sharma, Ishbal Ahmad, Sanjeev K Shukla, Rabi Sankar Bhatta, Sanjeev Kanojiya, Akhilesh Kumar Tamrakar, Koneni V Sashidhara |
| Journal | Phytochemistry (Phytochemistry) Vol. 201 Pg. 113286 (Sep 2022) ISSN: 1873-3700 [Electronic] England |
| PMID | 35752344 (Publication Type: Journal Article) |
| Copyright | Copyright © 2022 Elsevier Ltd. All rights reserved. |
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