HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

A variant in the fibronectin (FN1) gene, rs1250229-T, is associated with decreased risk of coronary artery disease in familial hypercholesterolaemia.

AbstractBACKGROUND:
Increased risk of coronary artery disease (CAD) in familial hypercholesterolaemia (FH) is modified by factors beyond defects in the low-density lipoprotein receptor pathway. The rs1250229-T single nucleotide polymorphism (SNP) in the FN1 gene is associated with CAD in genome-wide association studies and is in linkage disequilibrium with another SNP (rs1250259-T) in FN1 that is associated with decrease fibronectin secretion.
OBJECTIVE:
We investigated whether rs1250229-T was also associated with prevalent CAD in patients with genetically confirmed FH.
METHODS:
We collected clinical data from 256 patients with genetically confirmed FH. The FN1 rs1250229 SNP was genotyped on a SEQUENOM platform. The association between rs1250229-T and prevalent CAD was assessed using simple and multiple regression analyses.
RESULTS:
In patients with FH, the FN1 rs1250229-T (minor) allele was a significant negative predictor of prevalent CAD (odds ratio [OR] 0.353; 95% confidence interval [CI] 0.193 - 0.647; P = 0.001). FN1 rs1250229-T remained a significant predictor of prevalent CAD after adjusting for age, sex, obesity, hypertension, smoking status and lipoprotein(a) concentration (OR 0.200; 95% CI 0.091 - 0.441; P < 0.001).
CONCLUSION:
The FN1 rs1250229-T allele is inversely associated with CAD in patients with genetically confirmed FH, independently of traditional risk factors. While this finding requires replication, it suggests that the biology of fibronectin may contribute to variation in the risk of CAD in FH.
AuthorsMichael M Page, Katrina L Ellis, Dick C Chan, Jing Pang, Amanda J Hooper, Damon A Bell, John R Burnett, Eric K Moses, Gerald F Watts
JournalJournal of clinical lipidology (J Clin Lipidol) 2022 Jul-Aug Vol. 16 Issue 4 Pg. 525-529 ISSN: 1933-2874 [Print] United States
PMID35739058 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2022. Published by Elsevier Inc.
Chemical References
  • FN1 protein, human
  • Fibronectins
  • Lipoprotein(a)
Topics
  • Coronary Artery Disease (complications)
  • Fibronectins (genetics)
  • Genome-Wide Association Study
  • Humans
  • Hyperlipoproteinemia Type II (complications, genetics)
  • Lipoprotein(a) (genetics)
  • Risk Factors

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: