Background:
Dipeptidyl peptidase (DPP)-4 inhibitors are commonly used agents to treat
type 2 diabetes mellitus (T2DM). Although generally well tolerated,
stomatitis has been previously reported as an adverse event with
sitagliptin and
linagliptin.
Stomatitis with
alogliptin has not been reported in post-marketing data to date. Objective: To report a case of suspected
drug-induced
stomatitis in a patient who received
alogliptin for T2DM which resolved upon discontinuation of the offending agent. Summary: A 60-year-old male with T2DM began treatment with a
DPP-4 inhibitor,
alogliptin. After 4 doses of
alogliptin, the patient reported
inflammation and irritation along the lateral borders of his tongue, along with open fissures and oral ulcerations on the dorsal surface of the mucosa. He was subsequently diagnosed with
stomatitis. Patient discontinued
alogliptin and reported improvement in symptoms within 48 hours. Lesions re-epithelialized within 4 weeks after cessation of
alogliptin. The Naranjo Algorithm was used to assess causality. The total score was 7, which when interpreted, implicates
alogliptin as a "probable" cause of the reaction. Conclusion: A causality assessment determined
alogliptin was a "probable" cause of
stomatitis experienced by this patient. This adverse effect has not been reported with
alogliptin to the authors' knowledge.