Stomatitis

10/01/2010 - "A significant reduction in the incidence of radiation-induced oral mucositis by Palifermin has been demonstrated. "
10/01/2014 - "Assessment of the hamster cheek pouch as a model for radiation-induced oral mucositis, and evaluation of the protective effects of keratinocyte growth factor using this model."
10/01/2014 - "Additionally, palifermin when administered on days 1, 2 and 3 after irradiation (40 Gy) reduced the severity of oral mucositis. "
06/15/2010 - "Efficacy of palifermin (keratinocyte growth factor-1) in the amelioration of oral mucositis."
05/01/2009 - "Palifermin (recombinant human keratinocyte growth factor) reduces the severity of oral mucositis with HSCT. "

01/01/2023 - "At present, none of the guidelines recommend the use of various mouthwashes available for the treatment of oral mucositis. "
04/01/2022 - "The effectiveness of both mouthwashes was compared for their healing potential on oral mucositis by RTOG grading. "
01/01/2020 - "There is a wide variety of mouthwashes currently available for the prevention of intolerable oral mucositis (OM) onset. "
12/01/2008 - "The incidence of Grades 2-3 and Grade 3 oral mucositis was significantly reduced in patients who performed mouth rinse as compared with the controls (40 vs. 80%, P = 0.009; 0 vs. 25. "
01/01/2003 - "The alleviation of oral mucositis and the associated symptoms through promotion of an appropriate food/fluid intake and more frequent use of mouthwashes should be emphasized in oral care."

03/01/2024 - "Conclusion: PBM is feasible and effective in preventing and treating oral mucositis and is now supported by the Children's Oncology Group for prevention and treatment of oral mucositis in patients undergoing an allogeneic HCT or receiving head/neck radiation."
11/01/2023 - "Conclusions: PBM has been shown to be effective in preventing oral mucositis when applied to healthy tissues. "
09/01/2023 - "PBM can be used to improve the therapeutic efficacy of TMSCs for potential applications in oral mucositis and wound healing."
06/01/2022 - "Although PBM did not prevent oral mucositis, it decreased its severity (p < 0.01). "
11/01/2023 - "All studies showed good results for the use of PBM in the prevention of oral mucositis except for one study that found no benefit for the laser application. "

01/01/2020 - "We first determined the efficacy of lesional injection of tonsil-derived MSCs (mesenchymal stem cells) for the treatment of 5-fluorouracil induced oral mucositis. "
01/01/2021 - "Thirty-six albino male mice with oral mucositis induced by 5-FU as a chemotherapeutic agent were used in this study. "
06/01/2020 - "In this animal study, oral mucositis was induced in 30 male golden hamsters by 5-FU (60 mg/kg) on days 0, 5, and 10 of the study. "
09/29/2018 - "Prevent Fluorouracil-Induced Nuclear Factor-κB Activation in Oral Mucositis: In Vitro and In Vivo Studies."
06/01/2018 - "The aim of this study was to investigate the healing activity of andiroba (Carapa guianensis Aubl.) against oral mucositis (OM) induced by 5-fluorouracil in golden Syrian hamsters. "

11/01/2005 - "Experimental L-glutamine agent shown effective in oral mucositis."
06/01/2017 - "The present study revealed that glutamine provided slight clinical effects compared with placebo in terms of reducing oral mucositis induced by RT or CHRT in patients with HNC at the 6th week; however, the results were not statistically significant. "
11/05/2016 - "The aim of this study was to develop mucoadhesive nanofibers containing glutamine via electrospinning and to characterize them for the treatment of oral mucositis. "
01/01/2014 - "Role of oral glutamine in alleviation and prevention of radiation-induced oral mucositis: A prospective randomized study."
02/01/2000 - "Oral glutamine to alleviate radiation-induced oral mucositis: a pilot randomized trial."

10/24/2022 - "Dentoxol® is a medical solution in the form of a mouthwash that has been shown to result in statistically significant improvement in the prevention of severe oral mucositis. "
12/01/2023 - "To evaluate the efficacy of NAHAO® oral mucosal antibacterial care solution (NAHAO® spray) on attenuating oral mucositis (OM) symptoms and related mechanisms investigation. "
01/01/2019 - "It appears feasible to utilize RB nanoparticles dispersed in HPC-SSL solution in mouthwash to prevent stomatitis."
12/01/2017 - "A Sweet Solution: The Use of Medical-grade Honey on Oral Mucositis in the Pediatric Oncology Patient."
09/01/2014 - "Yarrow distillate-contained solution reduced stomatitis severity more than the routine solution. "

01/22/2019 - "brevis lozenges, Zync supplementation and Benzydamine are the best treatment or/and prevention methods for oral mucositis. "
01/01/2023 - "Turmeric mouthwash was effective in reducing the severity of oral mucositis and associated oral dysfunctions as compared with benzydamine mouthwash. "
01/01/2009 - "This study was a prospective, randomized clinical trial carried out to explore the efficacy of payayor in the prevention and relief of radiation-induced oral mucositis compared with benzydamine. "
03/01/2015 - "Efficacy of benzydamine oral rinse in prevention and management of radiation-induced oral mucositis: A double-blind placebo-controlled randomized clinical trial."
03/01/2015 - "Several studies have demonstrated positive effects of benzydamine oral rinse in prevention of radiation-induced oral mucositis. "

10/01/2002 - "Oral mucositis tended to be less severe in the GM-CSF group (p = 0.072). "
03/01/2002 - "Published literature assessing the use of GM-CSF to treat or prevent oral mucositis was analyzed. "
03/01/2002 - "To evaluate the effect of granulocyte macrophage-colony stimulating factor (GM-CSF) in patients with oral mucositis. "
03/01/2002 - "Granulocyte macrophage-colony stimulating factor and oral mucositis."
11/01/2001 - "Treatment for oral mucositis was initiated on day 2.7+/-1.2 (range: day 1-8) after onset of symptoms in the GM-CSF group and on day 1.8+/-1.4 (range: day 1-3; P=0.11) in the AA group. "

07/01/2019 - "Among 10 patients who developed grade 2 or more stomatitis in the non-oblate group and received oblate-covered everolimus, nine (90%) showed complete recovery or improved to grade 1, which persisted until discontinuation of everolimus. "
07/01/2019 - "Oblate-covered everolimus improved the incidence of and time to grade 2 or more stomatitis, although it was not statistically significantly different compared to the non-oblate group. "
02/01/2014 - "A 2-fold increase in everolimus Cmin was associated with improved tumour size reduction and increased risk of high-grade pulmonary, metabolic and stomatitis events. "
01/01/2020 - "Here we provide early evidence from the first randomized trial supporting the use of oral prophylactic mucoadhesive for everolimus-associated stomatitis. "
01/01/2020 - "This study hypothesized that professional oral care (POC) before everolimus treatment could reduce the incidence of everolimus-induced oral mucositis. "

09/01/2011 - "The review of literature included 5 studies fulfilling the inclusion criteria, in which chlorhexidine was evaluated and 4 studies showed a significant preventive effect on the development or severity of oral mucositis; the remaining study showed no benefit of using chlorhexidine mouthwash when compared with the placebo group. "
11/01/2015 - "Cost-effective analysis of topical chlorhexidine in hematologic patients at risk for oral mucositis."
01/01/2011 - "New form of administering chlorhexidine for treatment of denture-induced stomatitis."
12/01/2006 - "These results do not support the use of chlorhexidine mouthwash to prevent oral mucositis."
12/01/1994 - "To determine whether a chlorhexidine mouthwash could alleviate radiation-induced oral mucositis. "

01/01/2017 - "This case supports the need to conduct controlled studies comparing the efficacy of autologous and allogeneic platelet gel from adult and umbilical cord blood for the topical treatment of severe oral mucositis occurring after high-dose chemotherapy."
03/01/2019 - "The topical application of honey on oral mucosa was effective in reducing the severity and duration of management of chemotherapy induced oral mucositis (CIOM; p < 0.05) and that means honey is a good quality product with rich nutritious value and would be a pleasant, simple and cost-effective modality for the management of oral mucositis associated with chemotherapy."
01/01/2014 - "AESN showed protective effect in both models of oral mucositis; however, the higher dose was more effective in chemotherapy induced oral mucositis. "
08/01/2001 - "Although the management of patients with other chemotherapy-related toxicities has improved in recent years, the incidence of stomatitis is increasing because of more intensive treatment and is often a dose limiting factor in chemotherapy. "
03/24/2023 - "Thus, β-cry can alleviate the symptoms of chemotherapy-induced oral mucositis, and its combination with oral care is effective in managing oral mucositis."

11/01/2015 - "The results showed a significant reduction in mouth opening (p<0.001), right lateral excursion (p=0.038) and left lateral excursion (p=0.035) of the jaw, a significant increase in the presence (p<0.001) and severity of oral mucositis (p<0.001), and a significant decrease in performance status (p<0.001) after radiation therapy. "
12/01/2022 - "The results suggest that MDR replacement is superior to dental spacer fabrication in reducing the incidence of oral mucositis during head and neck radiotherapy, although MDR removal carries several associated risks."
03/01/2024 - "This study provides clinical caregivers with the evidence-based measures on managing radiotherapy-induced oral mucositis. "
12/01/2023 - "This small study included 11 patients treated by hypo-fractionated radiotherapy and assessed for oral mucositis. "
09/01/2023 - "This study was intended to investigate the association of most common single nucleotide polymorphisms of DNA repair genes with acute radiation induced toxicities such as skin reactions and oral mucositis in normal tissue from HNC patients receiving radiotherapy from South-Western Maharashtra. "

11/01/2008 - "However, muscular degeneration was observed in 18% of the samples of Group I. It may be concluded that the LED therapy protocol established for this in vivo study was effective in reducing the severity of oral mucositis, although the oral lesions were not completely prevented."
12/01/2008 - "LED therapy was a safe and effective method for preventing oral mucositis in this case report. "
01/01/2012 - "We aimed to evaluate the efficacy of LLL therapy to decrease severe oral mucositis and its effect on RT interruptions. "
01/01/2023 - "This study's population was HNC patients who had oral mucositis after receiving radiation or chemical therapy. "
06/01/2021 - "The number of studies identified as eligible was 151, including 47 randomized controlled trials, reporting a total of 3075 participants undergoing some therapy with natural products on oral mucositis. "

07/01/2012 - "Photomedicine using LLLT is very effective with intraoral and extraoral devices in the management of oral mucositis, based on several studies including randomized control studies. "
10/19/2023 - "Photobiomodulation was effective in the treatment of oral mucositis."
12/01/2023 - "The chromatographic constitution of andiroba oil and his healing effects, compared to the LLLT outcomes, in oral mucositis induced in golden Syrian hamsters: a new treatment option."
09/22/2023 - "Addendum: The chromatographic constitution of andiroba oil and its healing effects, compared to the LLLT outcomes, in oral mucositis induced in golden Syrian hamsters: a new treatment option."
12/01/2021 - "This review aimed to evaluate the efficacy of Photobiomodulation in the treatment of oral mucositis using meta-analysis and trial sequential analysis, and also to assess the quality of the results by Grading of Recommendations, Assessment, Development and Evaluation (GRADE). "

03/01/2007 - "In this multicenter randomized study, we addressed whether cryotherapy during MTX administration is effective in the prevention of severe oral mucositis in patients undergoing myeloablative AHSCT. "
03/01/2017 - "Oral cryotherapy has been documented to be potentially effective in reducing oral mucositis. "
07/01/1994 - "Oral cooling (cryotherapy), an effective treatment for the prevention of 5-fluorouracil-induced stomatitis."
03/01/2023 - "Efficacy of Cryotherapy and Hangeshashinto for Radiation-induced Oral Stomatitis: Preliminary Study."
01/08/2024 - "The use of oral cryotherapy markedly reduced the occurrence of overall (RR 0.72, 95% CI 0.64 to 0.83, n=20 trials), moderate to severe (RR 0.60, 95% CI 0.45 to 0.80, n=16 trials) and severe oral mucositis (RR 0.48, 95% CI 0.34 to 0.67, n=16 trials), as well as average severity score of oral mucositis (standardised mean difference=-0.94, 95% CI -1.28 to -0.59, n=4 trials) in comparison to a control group; however, the certainty of evidence for all outcomes was rated very low. "