Associations between endogenous sex hormones and FGF-23 among women and men in the Multi-Ethnic Study of Atherosclerosis.

Abstract

Elevated levels of testosterone and fibroblast growth factor 23 (FGF-23) are both independently associated with a higher risk of cardiovascular disease (CVD). However, the relationship between sex hormones and FGF-23 is not well established. We explored the association between sex hormones and FGF-23 among middle-aged to older men and women in MESA. We studied 3,052 men and 2,868 postmenopausal women free of CVD at the time of enrollment with baseline serum sex hormones [total testosterone (T), free T, estradiol (E2) and sex hormone binding globulin (SHBG)] and intact FGF-23. In sex-stratified analyses, we examined the cross-sectional associations between log-transformed sex hormones (per 1 SD) and log-transformed FGF-23 using multiple linear regression adjusted for socio-demographics, CVD risk factors, estimated glomerular filtration rate and mineral metabolites (25-hydroxyvitamin D, calcium, phosphorus and parathyroid hormone). The mean (SD) age of study participants was 64 (10) years. The median (IQR) of FGF-23 was similar in women and men [38 (30-46) vs 38 (31-47) pg/mL]. In adjusted analyses, among women, 1 SD increment in free T was associated with 3% higher FGF-23 while SHBG was associated with 2% lower FGF-23. In men, 1 SD increment in E2 was associated with 6% higher FGF-23 whereas total T/E2 ratio was associated with 7% lower FGF-23. In conclusion, this exploratory analysis found that a more androgenic sex hormone profile was directly associated with FGF-23 in women and inversely associated with FGF-23 in men. Longitudinal studies are required to determine whether FGF-23 mediates the relationship between sex hormones and CVD risk.

• Authors: Oluseye Ogunmoroti, Olatokunbo Osibogun, Di Zhao, Rupal C Mehta, Pamela Ouyang, Pamela L Lutsey, Cassianne Robinson-Cohen, Erin D Michos
• Journal: PloS one (PLoS One) Vol. 17 Issue 5 Pg. e0268759 ( 2022) ISSN: 1932-6203 [Electronic] United States
• PMID: 35613118 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural)

Chemical References

• FGF23 protein, human
• Gonadal Steroid Hormones
• Sex Hormone-Binding Globulin
• Testosterone
• Estradiol
• Fibroblast Growth Factor-23

Topics

• Adult
• Aged
• Atherosclerosis (blood)
• Cardiovascular Diseases (blood)
• Cross-Sectional Studies
• Estradiol (blood)
• Female
• Fibroblast Growth Factor-23 (blood)
• Gonadal Steroid Hormones (blood)
• Humans
• Male
• Middle Aged
• Sex Hormone-Binding Globulin (metabolism)
• Testosterone (blood)