Several Alkaloids in Chinese Herbal Medicine Exert Protection in Acute Kidney Injury: Focus on Mechanism and Target Analysis.

Abstract

Objectives:

Acute kidney injury (AKI) is a loose set of kidney diseases accompanied by a variety of syndromes, which is a serious threat to human life and health. Some alkaloids are derived from various Chinese herbs have been widely concerned in the improvement of AKI. This review provides the research progress of alkaloids in AKI experimental models and discusses the related molecular mechanisms. Key Findings. Alkaloids can protect AKI through various mechanisms including antioxidant stress, improvement of mitochondrial damage, reduction of cell death, induction of autophagy, and inhibition of inflammation. These mechanisms are mainly related to the activation of Nrf2/HO-1 signaling pathway, inhibition of ferroptosis and apoptosis, regulation of PINK1/Parkin pathway, inhibition of TLR4/NF-κB pathway and NLRP3 inflammatory bodies, upregulation of Klotho protein level and so on. In addition, there are a few alkaloids that have certain toxicity on the kidney.

Conclusion:

Alkaloids have been shown to significantly improve AKI, but only in pharmacological studies. This paper summarizes the main experimental models currently used in AKI research and describes some representative alkaloids based on recent research. Their potential roles in the prevention and treatment of AKI through different mechanisms are highlighted.

• Authors: Yixin Rui, Sheng Li, Fei Luan, Dan Li, Rong Liu, Nan Zeng
• Journal: Oxidative medicine and cellular longevity (Oxid Med Cell Longev) Vol. 2022 Pg. 2427802 ( 2022) ISSN: 1942-0994 [Electronic] United States
• PMID: 35602100 (Publication Type: Journal Article, Review)
• Copyright: Copyright © 2022 Yixin Rui et al.

Chemical References

• Alkaloids
• Drugs, Chinese Herbal
• NF-kappa B

Topics

• Acute Kidney Injury (drug therapy, metabolism, prevention & control)
• Alkaloids (pharmacology, therapeutic use)
• Animals
• Drugs, Chinese Herbal (pharmacology, therapeutic use)
• Humans
• Kidney (metabolism)
• NF-kappa B (metabolism)
• Signal Transduction