Trained immunity: implications for vaccination.

Abstract

The concept that only adaptive immunity can build immunological memory has been challenged in the past decade. Live attenuated vaccines such as the Bacillus Calmette-Guérin, measles-containing vaccines, and the oral polio vaccine have been shown to reduce overall mortality beyond their effects attributable to the targeted diseases. After an encounter with a primary stimulus, epigenetic and metabolic reprogramming of bone marrow progenitor cells and functional changes of tissue immune cell populations result in augmented immune responses against a secondary challenge. This process has been termed trained immunity. This review describes the mechanisms leading to trained immunity and summarizes the most important developments from the past few years.

• Authors: Büsranur Geckin, Friedrich Konstantin Föhse, Jorge Domínguez-Andrés, Mihai G Netea
• Journal: Current opinion in immunology (Curr Opin Immunol) Vol. 77 Pg. 102190 (08 2022) ISSN: 1879-0372 [Electronic] England
• PMID: 35597182 (Publication Type: Journal Article, Review, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2022 The Author(s). Published by Elsevier Ltd.. All rights reserved.

Chemical References

• BCG Vaccine

Topics

• Adaptive Immunity
• BCG Vaccine
• Humans
• Immunity, Innate
• Immunologic Memory
• Mycobacterium bovis
• Vaccination