Attenuated Vaccines

Live vaccines prepared from microorganisms which have undergone physical adaptation (e.g., by radiation or temperature conditioning) or serial passage in laboratory animal hosts or infected tissue/cell cultures, in order to produce avirulent mutant strains capable of inducing protective immunity.

Also Known As:

Networked: 1426 relevant articles (142 outcomes, 145 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Barrett, Alan D T: 9 articles (01/2022 - 07/2002)
2.	Netea, Mihai G: 7 articles (01/2022 - 10/2018)
3.	de la Torre, Juan Carlos: 7 articles (01/2020 - 06/2006)
4.	Monto, Arnold S: 7 articles (10/2017 - 12/2006)
5.	Monath, Thomas P: 7 articles (01/2010 - 01/2002)
6.	Locht, Camille: 6 articles (06/2022 - 04/2004)
7.	Martínez-Sobrido, Luis: 6 articles (01/2022 - 07/2015)
8.	Ye, Chengjin: 6 articles (10/2021 - 01/2020)
9.	Weaver, Scott C: 6 articles (09/2020 - 09/2008)
10.	Chang, Shuang: 6 articles (05/2019 - 03/2016)

Related Diseases

1.	Infections 01/01/2023 - "In our previous study, we generated a highly cell-passaged PEDV strain, CT-P120, which showed promise as a live attenuated vaccine candidate by providing satisfactory protection against variant PEDV infection in piglets. " 01/01/2019 - "Currently, the most efficient way to achieve protection against infection is immunization with live-attenuated vaccines. " 01/01/2013 - "Live attenuated vaccine (LAV), mimicking natural infection, provides an excellent protection against microbial infection. " 01/01/2021 - "Both natural infection and live-attenuated vaccine strain (LVS) confer good protection against tularaemia. " 11/01/2011 - "These results demonstrate, for the first time, that recombinant DEV is suitable for use as a bivalent live attenuated vaccine, providing rapid protection against both DEV and H5N1 virus infection in ducks."
2.	Human Influenza (Influenza) 11/09/2004 - "There are numerous RCTs of good quality in large populations that have consistently shown that influenza vaccination, using inactivated or live-attenuated vaccines, is moderately effective in preventing influenza in the general population (healthy adults and children over 6 months of age). " 05/01/2002 - "Live attenuated vaccines, also administered directly to the respiratory tract, have continued to be shown to be safe and effective, and, in the longer term, probably will have a major role in influenza prophylaxis, especially in children and young adults." 11/15/2011 - "Efficacy of live attenuated vaccines against 2009 pandemic H1N1 influenza in ferrets." 01/01/2020 - "At a site of a phase 3 randomized, double-blind, placebo-controlled clinical trial in eastern China, eligible healthy children aged 3-17 years underwent randomization to receive live attenuated vaccine or placebo at a ratio of 1:1. The primary objective of the study was the prevention of laboratory-confirmed influenza illness during the surveillance period, starting on day 15 after vaccination. " 05/01/2011 - "We compared characteristics of influenza A (H3N2) and B cases from 3 years of a comparative placebo-controlled trial of inactivated and live attenuated vaccines, and we evaluated the laboratory end points used to determine efficacy. "
3.	Measles 08/04/2022 - "Despite the existence of a safe and effective live attenuated vaccine, measles can appear in vaccinated individuals. " 01/01/2008 - "Despite the availability of an effective and safe live attenuated vaccine, measles remains a cause of continuing outbreaks in Japan. " 03/21/2001 - "Despite the availability of safe and effective live attenuated vaccines, measles continues to be endemic in many developing countries. " 07/01/2013 - "Oncolytic measles viruses (MV) derived from the live attenuated vaccine strain have been engineered for increased antitumor activity, and are currently under investigation in clinical phase 1 trials. " 12/01/1975 - "All Should Be Revaccinated Within 10-15 Years Of Primary Immunisation.(7) Children whose primary vaccination was by live ;further attenuated' vaccine before the age of two years may need to be revaccinated before they leave school, but this requires further study.(8) A case can be made for using a less attenuated strain of measles virus for revaccination than for primary vaccination.(9) The eventual need for and timing of revaccination against measles should be examined in a larger group of children."
4.	Virus Diseases (Viral Diseases) 01/01/2020 - "Live attenuated vaccines (LAV) are one of the best choices to obtain a strong early and long-lasting protection against viral diseases. " 06/01/2003 - "Live-attenuated vaccines are effective in stimulating immunity, however challenged animals rarely clear viral infection and the degree of attenuation directly correlates with the protection of animals from disease. " 05/01/2012 - "Fetal protection against bovine viral diarrhoea type 1 virus infection after one administration of a live-attenuated vaccine." 09/20/2023 - "This approach has the potential to enable wider use of attenuated vaccines for sustainable prevention against plant viral disease in the field." 09/20/2023 - "Control of plant viral diseases through cross-protection conferred by an attenuated vaccine is an important strategy for plant protection. "
5.	Poliomyelitis (Polio) 03/01/1996 - "The Czech Republic is one of the first countries where the paralytic form of poliomyelitis was eradicated by vaccination with the live attenuated vaccine. " 10/04/2017 - "Following the eradication of wild poliovirus (PV), achieving and maintaining a polio-free status will require eliminating potentially pathogenic PV strains derived from the oral attenuated vaccine. " 09/01/2013 - "This article presents what is considered the last phase of the eradication of polio in Spain, which took 25 years during the period 1963-1988, in the wake of the sharp decline that occurred in the incidence of the disease by introducing Sabin attenuated vaccine in 1963. " 11/01/2012 - "Risks associated with the use of live-attenuated vaccine poliovirus strains and the strategies for control and eradication of paralytic poliomyelitis. " 11/01/2012 - "Apropos risks associated with the use of live-attenuated vaccine poliovirus strains and the strategies for control and eradication of paralytic poliomyelitis."

Related Drugs and Biologics

1.	Vaccines
2.	Inactivated Vaccines
3.	Antibodies
4.	Antiviral Agents (Antivirals)
5.	Combined Vaccines
6.	Immunoglobulin G (IgG)
7.	Proteins (Proteins, Gene)
8.	Antigens
9.	ChimeriVax
10.	Subunit Vaccines

Related Therapies and Procedures

1.	Biological Therapy
2.	Injections
3.	Therapeutics
4.	Mucosal Administration
5.	Operative Surgical Procedures