Attenuated Vaccines

Live vaccines prepared from microorganisms which have undergone physical adaptation (e.g., by radiation or temperature conditioning) or serial passage in laboratory animal hosts or infected tissue/cell cultures, in order to produce avirulent mutant strains capable of inducing protective immunity.

Also Known As:

Networked: 246 relevant articles (25 outcomes, 14 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Ohmit, Suzanne E: 4 articles (12/2011 - 12/2006)
2.	Monto, Arnold S: 4 articles (12/2011 - 12/2006)
3.	Freire, Marcos S: 3 articles (08/2015 - 01/2002)
4.	Locht, Camille: 3 articles (09/2014 - 04/2004)
5.	Bonaldo, Myrna C: 3 articles (01/2014 - 01/2002)
6.	Galler, Ricardo: 3 articles (01/2014 - 01/2002)
7.	Chen, Chuang-Fu: 2 articles (08/2015 - 06/2015)
8.	Zhang, Yuanxing: 2 articles (08/2015 - 08/2013)
9.	Liu, Qin: 2 articles (08/2015 - 08/2013)
10.	Wang, Qiyao: 2 articles (08/2015 - 08/2013)

Related Diseases

1.	Infection 08/01/2002 - "Measles virus normally does not cause a persistent infection, no animal reservoir for measles virus exists, no vector is involved in its spread, only one serotype exists, the virus is antigenically stable and vaccination with the currently used live attenuated vaccines proved to be highly effective in preventing disease. " 01/01/2014 - "An area attracting considerable attention is the potential application of live attenuated vaccines to confer serotype-independent protection against mucosal and systemic infection. " 06/01/2003 - "Live-attenuated vaccines are effective in stimulating immunity, however challenged animals rarely clear viral infection and the degree of attenuation directly correlates with the protection of animals from disease. " 11/26/2006 - "In conclusion, protection against experimental infection in mice after one single shoot, and its potential for mucosal vaccination suggest that HSao-nanoparticles may represent a serious alternative to the conventional attenuated vaccines against S. " 08/01/2015 - "Given the fact that live attenuated vaccines often contain some potential risks in virulence recovery and spread infections, new approaches are greatly needed to improve their biological safety. "
2.	Human Influenza (Influenza) 11/09/2004 - "There are numerous RCTs of good quality in large populations that have consistently shown that influenza vaccination, using inactivated or live-attenuated vaccines, is moderately effective in preventing influenza in the general population (healthy adults and children over 6 months of age). " 05/01/2002 - "Live attenuated vaccines, also administered directly to the respiratory tract, have continued to be shown to be safe and effective, and, in the longer term, probably will have a major role in influenza prophylaxis, especially in children and young adults." 11/15/2011 - "Efficacy of live attenuated vaccines against 2009 pandemic H1N1 influenza in ferrets." 05/01/2011 - "We compared characteristics of influenza A (H3N2) and B cases from 3 years of a comparative placebo-controlled trial of inactivated and live attenuated vaccines, and we evaluated the laboratory end points used to determine efficacy. " 06/01/2013 - "Vaccination against potential pandemic strains is one strategy in planning for future influenza pandemics; however, the success of live attenuated vaccines for H5N1 has been limited, due to poor replication in the human upper respiratory tract (URT). "
3.	Measles 03/21/2001 - "Despite the availability of safe and effective live attenuated vaccines, measles continues to be endemic in many developing countries. " 04/26/2012 - "The development of a measles subunit vaccine may circumvent the limitations associated with the current live attenuated vaccines and eventually contribute to global measles eradication. " 12/01/2008 - "Live attenuated vaccines against measles have been developed through adaptation of clinical isolates of measles virus (MV) in various cultured cells. " 11/01/2003 - "Many live attenuated vaccines for measles virus have been developed using either the prototype Edmonston strain or other locally isolated measles strains. " 10/12/2001 - "Measles remains a major cause of worldwide infant mortality despite the use of current live attenuated vaccines. "
4.	Mumps 03/01/1997 - "The action of live attenuated vaccines against mumps is poorly understood although their clinical efficacy is beyond doubt. " 06/01/1990 - "Widespread use of safe and effective live attenuated vaccines has dramatically reduced the incidence of rubella, congenital rubella, and mumps in the United States. " 10/01/2002 - "The introduction of live attenuated vaccines, either singly or as the measles-mumps-rubella combined vaccine, has dramatically reduced the occurrence of disease and in countries where vaccine uptake is high, indigenous disease has been virtually eliminated. " 04/01/2008 - "It combines the components from two well-established, live, attenuated vaccines against measles, mumps and rubella. " 07/01/2005 - "Here, we investigated the oncolytic potential of two commercially available live attenuated vaccines, Moraten measles and Jeryl-Lynn mumps, in a murine model of intraperitoneal human ovarian cancer and compared their efficacies against a recombinant oncolytic measles virus (MV-CEA) that is being tested in a phase I clinical trial. "
5.	Rubella (German Measles) 06/01/1990 - "Widespread use of safe and effective live attenuated vaccines has dramatically reduced the incidence of rubella, congenital rubella, and mumps in the United States. " 12/01/2011 - "Because human is only a natural host of the virus and effective live attenuated vaccines are available, immunization activities are strengthened globally to eliminate rubella and CRS, together with measles." 07/01/1978 - "Control of measles and rubella through use of attenuated vaccines." 10/01/2002 - "The introduction of live attenuated vaccines, either singly or as the measles-mumps-rubella combined vaccine, has dramatically reduced the occurrence of disease and in countries where vaccine uptake is high, indigenous disease has been virtually eliminated. " 04/01/2008 - "It combines the components from two well-established, live, attenuated vaccines against measles, mumps and rubella. "

Related Drugs and Biologics

1.	Vaccines
2.	Inactivated Vaccines
3.	DNA (Deoxyribonucleic Acid)
4.	Antibodies
5.	Antigens
6.	Subunit Vaccines
7.	tebufenozide (Mimic)
8.	MicroRNAs (MicroRNA)
9.	Yellow Fever Vaccine (Vaccine, Yellow Fever)
10.	Proteins (Proteins, Gene)

Related Therapies and Procedures

1.	Therapeutics
2.	Transplantation (Transplant Recipients)
3.	Transplants (Transplant)
4.	Artificial Skin
5.	Organ Transplantation