Most
wound dressings encounter a series of problems when dealing with the
bacterial infection of
wounds, for example, the antibacterial and
antioxidant capacities, comfort, and mechanical properties are not suitable to meet clinical requirements. Here, we synthesized ε-
polylysine-grafted nanocellulose (NCF-EPL) and
polydopamine (PDA) nanoparticles and embedded them in
genipin-cross-linked
gelatin to prepare a
hydrogel (NCF-EPL/
GTP/PDA). In this system, the embedded NCF-EPL and PDA interact with the
gelatin matrix to form a
hydrogel with excellent physical properties. The
hydrogel has broad-spectrum antibacterial abilities and good
antioxidant performance, and it can effectively promote cell proliferation. Full-thickness MRSA-infected skin wound healing experiments clearly show that the NCF-EPL/
GTP/PDA
hydrogel can significantly accelerate the healing of infected
wounds via killing bacteria and reducing
inflammation, and secondary damage caused by adhesion during dressing use is effectively avoided. In short, the
hydrogel provides a new method for overcoming the shortcomings of traditional dressings, and this approach provides further solutions for the selection of clinical dressings for healing
wounds.