Hereditary sensory and autonomic neuropathies (HSANs) include hereditary disorders that cause
congenital insensitivity to pain. Moreover, patients diagnosed with such disorders are known to have genetic mutations that alter their deep
pain sensation, making them more prone to developing bone and joint complications such as repetitive fractures, joint swelling, and Charcot
arthropathy. Neuropathic
arthropathy (
Charcot joint) is a rare and relatively poorly understood condition; it is suggested to be caused by autonomic dysfunction and repetitive microtrauma and characterized by instability and joint destruction. Diagnosing the idiopathic
Charcot joint is challenging and is considered to be a diagnosis of exclusion. In addition, there are limited cases of Charcot knees managed by
arthroplasty. Patients with Charcot knees are commonly characterized by profound bone loss, diffuse
synovitis, and instability in the knee joint. In this article, we report the case of a 13-year-old patient with known NTRK1 gene mutation who presented with recurrent knee joint swelling episodes and instability without
pain. She was diagnosed with Charcot knee joint and underwent right hinged
total knee replacement. At one-year follow-up, she continued to have good knee stability and an overall functional gait. Our findings suggest that managing Charcot knee joint with
total knee replacement in patients with
HSAN may show improvement in terms of stability, swelling, and overall gait.