Abstract | INTRODUCTION: AIM: MATERIALS AND METHODOLOGY: Hospital based, single centre, randomized, single blind, phase 3 control trial. First 140 patients with moderately severe and severe acute pancreatitis admitted in hospital in the given period who met the inclusion and exclusion criteria were taken. 70 patients were placed in the control and the trial group each by simple randomization (closed envelope method). The control group received conventional treatment for pancreatitis & the trial group received 1mg/kg body weight Enoxaperin, subcutaneously, 12 hourly for seven days along with the conventional treatment. Progression of disease in Computed Tomography Severity Index and incidence of pancreatic necrosis were the main outcomes studied at the end of 7 days of treatment. RESULTS: 1386 acute abdomen cases were screened, of which 269 were diagnosed with acute pancreatitis. 147 patients with acute pancreatitis met the selection criteria and 7 were dropouts. Recruitment started on April 9, 2021 and closed on December 5, 2021. Computed Tomography Severity Index progressed in 22(31.40%) patients in control group and 6(8.6%) patients in the trial group and 18(25.71%) in the control group and 4(5.71%) in the trial group showed the presence of necrosis. The differences are significant (P value is 0.001 in each). No adverse events were seen. CONCLUSION:
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Authors | Basavaraj Patil, Laxmi Narayan Meena, Dinesh Chandra Sharma, Garima Agarwal, Yogendra Dadhich, Gaurav Gupta |
Journal | International journal of surgery (London, England)
(Int J Surg)
Vol. 101
Pg. 106621
(May 2022)
ISSN: 1743-9159 [Electronic] United States |
PMID | 35489648
(Publication Type: Clinical Trial, Phase III, Journal Article, Randomized Controlled Trial)
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Copyright | Copyright © 2022 IJS Publishing Group Ltd. Published by Elsevier Ltd. All rights reserved. |
Chemical References |
- Anti-Inflammatory Agents
- Heparin, Low-Molecular-Weight
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Topics |
- Acute Disease
- Anti-Inflammatory Agents
- Heparin, Low-Molecular-Weight
(adverse effects)
- Humans
- Pancreatitis, Acute Necrotizing
- Single-Blind Method
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