Seroprevalence of SARS-CoV-2-specific antibodies and vaccination-related adverse events in systemic lupus erythematosus and rheumatoid arthritis.

Abstract

BACKGROUND:

This study aimed to investigate the seroreactivity of Coronavirus disease 2019 (COVID-19) vaccination and its adverse events among systemic lupus erythematosus (SLE) patients, rheumatoid arthritis (RA) patients, and healthy controls (HCs).

METHODS:

A total of 60 SLE patients, 70 RA patients and 35 HCs, who received a complete inactivated COVID-19 vaccine (Vero cells) regimen, were recruited in the current study. Serum IgG and IgM antibodies against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) were determined by using chemiluminescent microparticle immunoassay (CMIA).

RESULTS:

There were no significant differences regarding the seroprevalences of IgG and IgM antibodies against SARS-CoV-2, and the self-reported vaccination-related adverse events among SLE patients, RA patients and HCs. The inactivated COVID-19 vaccines appeared to be well-tolerated and moderately immunogenic. In addition, case-only analysis indicated that in SLE patients, the disease manifestation of rash and anti-SSA autoantibody were associated with seroprevalence of IgG antibody against SARS-CoV-2, whereas the uses of ciclosporin and leflunomide had influence on the seroprevalence of IgM antibody against SARS-CoV-2. In RA patients, rheumatoid factor (RF) appeared to be associated with the seroprevalence of IgG antibody against SARS-CoV-2.

CONCLUSION:

Our study reveals that the seroprevalences of IgG and IgM antibodies against SARS-CoV-2 and vaccination-related adverse effects are similar among SLE, RA and HCs, suggesting that COVID-19 vaccine is safe and effective for SLE and RA patients to prevent from the pandemic of COVID-19.

• Authors: Peng Wang, Jing Ni, Ya-Ya Chu, Qing-Qing Chen, Guo-Cui Wu, Yang Fang, Cong Chen, Ruo-Di Zhang, Ling-Qiong Jiang, Yan Zhao, Xi Fang, Jun He, De-Guang Wang, Gui-Hong Wang, Hai-Feng Pan
• Journal: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie (Biomed Pharmacother) Vol. 150 Pg. 112997 (Jun 2022) ISSN: 1950-6007 [Electronic] France
• PMID: 35486976 (Publication Type: Journal Article)
• Copyright: Copyright © 2022 The Authors. Published by Elsevier Masson SAS.. All rights reserved.

Chemical References

• Antibodies, Viral
• COVID-19 Vaccines
• Immunoglobulin G
• Immunoglobulin M

Topics

• Animals
• Antibodies, Viral
• Arthritis, Rheumatoid (complications, drug therapy, epidemiology)
• COVID-19 (epidemiology, prevention & control)
• COVID-19 Vaccines (adverse effects)
• Chlorocebus aethiops
• Humans
• Immunoglobulin G
• Immunoglobulin M
• Lupus Erythematosus, Systemic
• SARS-CoV-2
• Seroepidemiologic Studies
• Vaccination
• Vero Cells