Abstract | BACKGROUND:
Verbascoside, a representative phenylethanoid glycoside, is widely distributed in plants and has various activities beneficial for human health. Although systemically administered verbascoside has an antinociceptive effect, little is known about the site and mechanism of its activity. The aim of the present study was to determine whether verbascoside attenuates neuropathic pain in the spinal cord and which pain regulatory systems are involved. METHODS: Chronic constriction injury of the sciatic nerve was introduced to male Sprague Dawley rats. The effects of intrathecal administration of verbascoside and its components ( caffeic acid and hydroxytyrosol) on mechanical hyperalgesia and cold hyperalgesia were examined using the electronic von Frey test and cold-plate test, respectively. Several antagonists of spinal pain processing receptors were administered intrathecally to evaluate their effects on the antihyperalgesic action of verbascoside. A rotarod test was performed to assess the effects on motor coordination. RESULTS: CONCLUSIONS: SIGNIFICANCE: Currently available treatments for neuropathic pain have limited efficacy in most patients. Some natural products have favourable biological activities for long-term administration such as antioxidative and neuroprotective effects. Verbascoside inhibits spinal nociceptive transmission without serious side effects to the same degree as gabapentin, a first-line remedy for neuropathic pain. Natural products may be promising candidates for novel treatments of neuropathic pain.
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Authors | Koji Hara, Yasunori Haranishi, Tadanori Terada |
Journal | European journal of pain (London, England)
(Eur J Pain)
Vol. 26
Issue 6
Pg. 1322-1332
(07 2022)
ISSN: 1532-2149 [Electronic] England |
PMID | 35437876
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2022 European Pain Federation - EFIC®. |
Chemical References |
- Analgesics
- Biological Products
- Glucosides
- Phenols
- Receptors, Opioid
- Receptors, Opioid, mu
- acteoside
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Topics |
- Analgesics
(pharmacology, therapeutic use)
- Animals
- Biological Products
(therapeutic use)
- Constriction
- Disease Models, Animal
- Glucosides
- Humans
- Hyperalgesia
(drug therapy)
- Male
- Neuralgia
(drug therapy)
- Phenols
- Rats
- Rats, Sprague-Dawley
- Receptors, Opioid
- Receptors, Opioid, mu
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