Glioma is the most common
tumor of central nervous system in adults with poor prognosis. Yippee Like 1 (YPEL1) is a newly discovered
protein that plays contradictory roles in
pancreatic cancer and
colon cancer. Here we initially explored the expression, clinical significance, and function of YPEL1 in
glioma. The transcription level of YPEL1 in
glioma patients was extracted from TCGA datasets via GEPIA website. As a result, the
mRNA level of YPEL1 was significantly lower in
glioma tissues than that in normal brain tissues. Immunohistochemistry staining was next conducted to test
protein expression of YPEL1 in
glioma tissues (n = 130). Consistently, lower
protein expression of YPEL1 was observed in cases with larger
tumor size and advanced WHO grades. Univariate and multivariate analyses identified YPEL1 as a novel independent prognostic factor of
gliomas. Finally, overexpression of YPEL1 was performed in U87 and U373 cell lines to further validate its
tumor-related functions, followed by proliferation, invasion, and subcutaneous mice xenografts assays. In vitro and in vivo data demonstrated that overexpressing YPEL1 can remarkably prevent
glioma cell proliferation and invasion. Taken together, our data revealed that low YPEL1 expression was significantly correlated with poor overall survival of
glioma patients and may play anti-
tumor effects.