Meta-Analysis of the Efficacy and Safety of Alendronate Combined with Atorvastatin in the Treatment of Osteoporosis in Diabetes Mellitus.

Abstract

OBJECTIVE:

Diabetes is a chronic disease caused by defective insulin secretion in the body, resulting in metabolic abnormalities with persistent blood glucose elevation. Osteoporosis is the most common diabetes complication. The aim of this study was to perform a meta-analysis of the effects of alendronate combined with atorvastatin compared with alendronate alone in the treatment of osteoporosis in diabetes mellitus.

METHODS:

Two researchers independently used PubMed, ScienceDirect, Cochrane Library, Wanfang Data, CNKI, and VIP databases to search for all relevant studies that met the inclusion criteria and used RevMan 5.3 and STATA 16.0 for data analysis.

RESULTS:

Fourteen studies that met the inclusion criteria were selected, including 1456 patients. Among the data extracted in this meta-analysis, bone mineral density (BMD) was the primary outcome measurement, while total effective rate, VAS, osteoprotegerin (OPG), bone Gla protein (BGP), bone alkaline phosphatase (BAP), blood P and Ca, and adverse effects were secondary outcome measurements. Our results showed that alendronate combined with atorvastatin is more effective than alendronate alone, with higher BMD, OPG, BGP, and BAP, more significant pain relief, and fewer adverse events.

CONCLUSION:

The results of this meta-analysis indicate that alendronate combined with atorvastatin is a better treatment for osteoporosis in diabetes mellitus, showing more effective and higher BMD and fewer adverse events than alendronate alone.

• Authors: Zhencheng Xiong, Ping Yi, Xiangsheng Tang, Li Shu, Chi Zhang
• Journal: BioMed research international (Biomed Res Int) Vol. 2022 Pg. 6747469 ( 2022) ISSN: 2314-6141 [Electronic] United States
• PMID: 35178452 (Publication Type: Journal Article, Meta-Analysis)
• Copyright: Copyright © 2022 Zhencheng Xiong et al.

Chemical References

• Bone Density Conservation Agents
• Osteocalcin
• Atorvastatin
• Alkaline Phosphatase
• Alendronate

Topics

• Alendronate (pharmacology, therapeutic use)
• Alkaline Phosphatase
• Atorvastatin (pharmacology, therapeutic use)
• Bone Density
• Bone Density Conservation Agents (pharmacology)
• Diabetes Mellitus (drug therapy)
• Female
• Humans
• Osteocalcin
• Osteoporosis (complications, drug therapy)
• Osteoporosis, Postmenopausal