Long non-coding RNAs (lncRNAs) are a class of functional
RNA molecules that do not encode
proteins and are composed of more than 200
nucleotides. LncRNAs play important roles in epigenetic and gene expression regulation. The oncogenic
lncRNA GACAT3 was recently discovered to be dysregulated in many
tumors. Aberrant expression of GACAT3 contributes to clinical characteristics and regulates multiple oncogenic processes. The association of GACAT3 with a variety of
tumors makes it a promising
biomarker for diagnosis, prognosis, and targeted
therapy. In this review, we integrate the current understanding of the pathological features, biological functions, and molecular mechanisms of GACAT3 in
cancer. Additionally, we provide insight into the utility of GACAT3 as an effective diagnostic and prognostic marker for specific
tumors, which offers novel opportunities for targeted therapeutic intervention.