Total cholesterol: a potential mediator of the association between exposure to acrylamide and hypertension risk in adolescent females.

Abstract

Acrylamide (AA) exposure is associated with a range of adverse health effects. However, whether AA exposure is related to hypertension in adolescents remains unclear. The associations of blood hemoglobin biomarkers of AA (HbAA) and its metabolite glycidamide (HbGA) with hypertension risk, diastolic blood pressure (DBP), and systolic blood pressure (SBP) were evaluated by multivariate logistic regression and linear regression. We identified a potential positive association between blood HbGA and hypertension risk in adolescent females (OR 1.81, 95% CI 1.00-3.30; P for trend = 0.022); however, there was no correlation in the non-linear model (P = 0.831). In the sex-stratified linear models, blood HbGA level had a strong positive association with SBP in adolescent females (beta 0.84, 95% CI 0.13-1.55, P = 0.020). Mechanistically, a one-unit increase in blood HbGA (ln transformed) was associated with a 2.83 mg/dL increase in total cholesterol (TC) among females in the fully adjusted model. Mediation analysis showed that TC mediated 24.15% of the association between blood HbGA level and the prevalence of hypertension in females. The present results provide epidemiological evidence that exposure to AA, mainly its metabolite glycidamide, is positively associated with the prevalence of hypertension or increased SBP in adolescent females.

• Authors: Jingjia Liang, Cheng Xu, Qian Liu, Zhenkun Weng, Xin Zhang, Jin Xu, Aihua Gu
• Journal: Environmental science and pollution research international (Environ Sci Pollut Res Int) Vol. 29 Issue 25 Pg. 38425-38434 (May 2022) ISSN: 1614-7499 [Electronic] Germany
• PMID: 35079972 (Publication Type: Journal Article)
• Copyright: © 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.

Chemical References

• Hemoglobins
• Acrylamide
• Cholesterol

Topics

• Acrylamide (metabolism)
• Adolescent
• Blood Pressure
• Cholesterol
• Female
• Hemoglobins (metabolism)
• Humans
• Hypertension (chemically induced, epidemiology)
• Nutrition Surveys