Abstract | OBJECTIVE: METHODS: RESULTS:
Intraperitoneal injection of dextrose significantly increased blood glucose level. That was associated with aggravation of neurological deficits in hyperglycemic compared to normoglycemic animals. A total of 73 differentially expressed microRNAs were identified via transcriptomics analysis. Bioinformatics analyses showed that these microRNAs were significantly altered in several signaling pathways, of which the hedgehog signaling pathway was regarded as the most potential pathway associated with the effect of hyperglycemia on acute intracerebral hemorrhage. Furthermore, polymerase chain reaction results validated the correlation between microRNAs and hedgehog signaling pathway. CONCLUSIONS:
MicroRNA elevated in hyperglycemia group may be involved in worsening the neurological function via inhibiting the hedgehog signaling, which provides a novel molecular physiological mechanism and lays the foundation for treatment of intracerebral hemorrhage.
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Authors | Wen-Song Yang, Yi-Qing Shen, Xun Yang, Xin-Hui Li, Shao-Hua Xu, Li-Bo Zhao, Rui Li, Xin Xiong, Shun-Jie Bai, Qing-Yuan Wu, Anatol Manaenko, Qi Li, Peng Xie |
Journal | Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association
(J Stroke Cerebrovasc Dis)
Vol. 31
Issue 3
Pg. 106281
(Mar 2022)
ISSN: 1532-8511 [Electronic] United States |
PMID | 35026495
(Publication Type: Journal Article, Randomized Controlled Trial, Veterinary)
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Copyright | Copyright © 2021 Elsevier Inc. All rights reserved. |
Chemical References |
- Hedgehog Proteins
- MicroRNAs
- Glucose
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Topics |
- Animals
- Cerebral Hemorrhage
(genetics)
- Disease Models, Animal
- Glucose
(toxicity)
- Hedgehog Proteins
(metabolism)
- Hyperglycemia
(chemically induced)
- Male
- Mice
- Mice, Inbred C57BL
- MicroRNAs
- Signal Transduction
- Transcriptome
(genetics)
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