Abstract | BACKGROUND: METHODS: Biopsies were performed on native kidney and at 1 and 5 months after transplantation. Semaphorin 3B antigen was detected in immune deposits by immunohistochemistry and confocal microscopy on paraffin-embedded biopsies. Anti- semaphorin antibodies were detected by Western blot and analyzed sequentially. RESULTS: CONCLUSION: This case provides evidence that anti- semaphorin 3B antibodies are pathogenic and should be monitored in patients with MN.
|
Authors | Marc Fila, Hanna Debiec, Hélène Perrochia, Nabila Djouadi, Marie-Christine Verpont, David Buob, Pierre Ronco |
Journal | Journal of the American Society of Nephrology : JASN
(J Am Soc Nephrol)
Vol. 33
Issue 3
Pg. 503-509
(03 2022)
ISSN: 1533-3450 [Electronic] United States |
PMID | 35017170
(Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)
|
Copyright | Copyright © 2022 by the American Society of Nephrology. |
Chemical References |
- Receptors, Phospholipase A2
- Semaphorins
- Rituximab
|
Topics |
- Adult
- Autoimmune Diseases
- Child
- Female
- Glomerulonephritis, Membranous
- Humans
- Kidney Transplantation
(adverse effects)
- Male
- Receptors, Phospholipase A2
- Recurrence
- Rituximab
- Semaphorins
|