The progesterone-receptor modulator, ulipristal acetate, drastically lowers breast cell proliferation.

Abstract

PURPOSE:

The proliferation of breast epithelial cells increases during the luteal phase of the menstrual cycle, when they are exposed to progesterone, suggesting that ulipristal acetate, a selective progestin-receptor modulator (SPRM), may reduce breast cell proliferation with potential use in breast cancer chemoprevention.

METHODS:

Women aged 18-39 were randomized 1:1 to ulipristal 10-mg daily or to a combination oral contraceptive (COC) for 84 days. Participants underwent a breast biopsy and breast MRI at baseline and at end of study treatment. Proliferation of breast TDLU cells was evaluated by Ki67 immunohistochemical stain. We evaluated the breast MRIs for background parenchymal enhancement (BPE). All slides and images were masked for outcome evaluation.

RESULTS:

Twenty-eight treatment-compliant participants completed the study; 25 of whom had evaluable Ki67 results at baseline and on-treatment. From baseline to end of treatment, Ki67 % positivity (Ki67%+) decreased a median of 84% in the ulipristal group (N = 13; 2-sided p (2p) = 0.040) versus a median increase of 8% in the COC group (N = 12; 2p = 0.85). Median BPE scores decreased from 3 to 1 in the ulipristal group (p = 0.008) and did not decrease in the COC group.

CONCLUSION:

Ulipristal was associated with a major decrease in Ki67%+ and BPE. Ulipristal would warrant further investigation for breast cancer chemoprevention were it not for concerns about its liver toxicity. Novel SPRMs without liver toxicity could provide a new approach to breast cancer chemoprevention.

TRIAL REGISTRATION:

NCT02922127, 4 October 2016.

• Authors: Carolyn L Westhoff, Hua Guo, Zhong Wang, Hanina Hibshoosh, Margaret Polaneczky, Malcolm C Pike, Richard Ha
• Journal: Breast cancer research and treatment (Breast Cancer Res Treat) Vol. 192 Issue 2 Pg. 321-329 (Apr 2022) ISSN: 1573-7217 [Electronic] Netherlands
• PMID: 35015210 (Publication Type: Journal Article, Randomized Controlled Trial)
• Copyright: © 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

Chemical References

• Norpregnadienes
• Receptors, Progesterone
• Progesterone
• ulipristal acetate

Topics

• Adolescent
• Adult
• Breast Neoplasms (drug therapy)
• Cell Proliferation
• Female
• Humans
• Leiomyoma
• Norpregnadienes
• Progesterone
• Receptors, Progesterone
• Young Adult