Peptide Modified Albumin-Paclitaxel Nanoparticles for Improving Chemotherapy and Preventing Metastasis.

Abstract

Metastasis and recurrence are the main causes of death in cancer patients; however, there are few medicines that can inhibit tumor growth and metastasis at the same time. In this work, a novel nano-drug delivery system (NDDS) based on targeting ligand modified albumin is reported. The hydrophobic drug (paclitaxel) induces albumin self-assembly after treatment of albumin with l-cysteine, forming drug-loaded nanoparticles with a size of 100-200 nm. Importantly, the albumin nanoparticles display enhanced antitumor efficacy against tumor growth/lung metastasis in 4T1 bearing nude mice and prevention of lung metastasis in a B16-F10 model. This study provides a facile method for hydrophobic chemo-drugs loaded albumin nanoparticles preparation and a promising chemotherapy with effective tumor growth inhibition and metastasis prevention.

• Authors: Ying Fu, Shuyan Yang, Yuning Liu, Jian Liu, Qizhi Wang, Fengyan Li, Xiuzhuan Shang, Yuou Teng, Na Guo, Peng Yu
• Journal: Macromolecular bioscience (Macromol Biosci) Vol. 22 Issue 3 Pg. e2100404 (03 2022) ISSN: 1616-5195 [Electronic] Germany
• PMID: 34964544 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2022 Wiley-VCH GmbH.

Chemical References

• Albumins
• Peptides
• Paclitaxel

Topics

• Albumins (chemistry, pharmacology)
• Animals
• Cell Line, Tumor
• Humans
• Lung Neoplasms (drug therapy, secondary)
• Mice
• Mice, Inbred BALB C
• Mice, Nude
• Nanoparticles (chemistry)
• Paclitaxel (chemistry)
• Peptides